BindingDB logo
myBDB logout

BDBM50022419 6-fluoro-1'-methyl-(4'S)-spiro[3,4-dihydro-2H-chromene-4,4'-(1'H,2'H-imidazole)]-2',5'-dione::CHEMBL79978

SMILES: CN1C(=O)N[C@]2(CCOc3ccc(F)cc23)C1=O

InChI Key: InChIKey=BMQSVFPKUMYFGH-LBPRGKRZSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50022419   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50022419
PNG
(6-fluoro-1'-methyl-(4'S)-spiro[3,4-dihydro-2H-chro...)
Show SMILES CN1C(=O)N[C@]2(CCOc3ccc(F)cc23)C1=O
Show InChI InChI=1S/C12H11FN2O3/c1-15-10(16)12(14-11(15)17)4-5-18-9-3-2-7(13)6-8(9)12/h2-3,6H,4-5H2,1H3,(H,14,17)/t12-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards partially purified human placenta aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair