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BDBM50022458 6'-chlorospiro[tetrahydro-1H-imidazole-4,4'-(3',4'-dihydro-2'H-thiochromene)]-2,5-dione::CHEMBL307847

SMILES: Clc1ccc2SCCC3(NC(=O)NC3=O)c2c1

InChI Key: InChIKey=GZWXPPVSYXZBMY-UHFFFAOYNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50022458   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022458
PNG
(6'-chlorospiro[tetrahydro-1H-imidazole-4,4'-(3',4'...)
Show SMILES Clc1ccc2SCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1/C11H9ClN2O2S/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)
PDB

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CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair