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BDBM50022499 7-methoxyspiro[3,4-dihydro-2H-benzo[h]chromene-4,4'-(tetrahydro-1'H-imidazole)]-2',5'-dione::CHEMBL309998

SMILES: COc1cccc2c3OCCC4(NC(=O)NC4=O)c3ccc12

InChI Key: InChIKey=UUSHVFLXLPNAAP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50022499   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022499
PNG
(7-methoxyspiro[3,4-dihydro-2H-benzo[h]chromene-4,4...)
Show SMILES COc1cccc2c3OCCC4(NC(=O)NC4=O)c3ccc12
Show InChI InChI=1S/C16H14N2O4/c1-21-12-4-2-3-10-9(12)5-6-11-13(10)22-8-7-16(11)14(19)17-15(20)18-16/h2-6H,7-8H2,1H3,(H2,17,18,19,20)
PDB

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair