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BDBM50024522 (4-Chloro-phenyl)-(4-fluoro-phenyl)-pyrimidin-5-yl-methanol::CHEMBL282325

SMILES: OC(c1ccc(F)cc1)(c1ccc(Cl)cc1)c1cncnc1

InChI Key: InChIKey=OCYZFOMLYIWENI-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50024522   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50024522
PNG
((4-Chloro-phenyl)-(4-fluoro-phenyl)-pyrimidin-5-yl...)
Show SMILES OC(c1ccc(F)cc1)(c1ccc(Cl)cc1)c1cncnc1
Show InChI InChI=1S/C17H12ClFN2O/c18-15-5-1-12(2-6-15)17(22,14-9-20-11-21-10-14)13-3-7-16(19)8-4-13/h1-11,22H
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PC cid
PC sid
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Similars

Article
PubMed
n/an/an/an/a 180n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]androstenedione and NADPH-generating system.


J Med Chem 30: 1359-65 (1987)


Article DOI: 10.1021/jm00391a016
BindingDB Entry DOI: 10.7270/Q2NP251P
More data for this
Ligand-Target Pair