BDBM50025808 1-(2,3,5,6-Tetrafluoro-4-hydroxy-benzyl)-1,3-dihydro-imidazole-2-thione::CHEMBL63145

SMILES Oc1c(F)c(F)c(Cn2cc[nH]c2=S)c(F)c1F

InChI Key InChIKey=KYIHFYLXPPNAKG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50025808   

TargetDopamine beta-hydroxylase(Bos taurus)
TBA

Curated by ChEMBL
LigandPNGBDBM50025808(1-(2,3,5,6-Tetrafluoro-4-hydroxy-benzyl)-1,3-dihyd...)
Affinity DataIC50:  6.20E+4nMAssay Description:Inhibitory Concentration against bovine Dopamine beta hydroxylase (DBH); Range is betwen (56-72).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDopamine beta-hydroxylase(Homo sapiens (Human))
Molecular Simulations

Curated by ChEMBL
LigandPNGBDBM50025808(1-(2,3,5,6-Tetrafluoro-4-hydroxy-benzyl)-1,3-dihyd...)
Affinity DataIC50:  6.17E+4nMAssay Description:Inhibition of dopamine beta hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDopamine beta-hydroxylase(Homo sapiens (Human))
Molecular Simulations

Curated by ChEMBL
LigandPNGBDBM50025808(1-(2,3,5,6-Tetrafluoro-4-hydroxy-benzyl)-1,3-dihyd...)
Affinity DataIC50:  6.17E+4nMAssay Description:Inhibition of dopamine beta-hydroxylase (DbetaH) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDopamine beta-hydroxylase(Rattus norvegicus)
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM50025808(1-(2,3,5,6-Tetrafluoro-4-hydroxy-benzyl)-1,3-dihyd...)
Affinity DataIC50:  6.17E+4nMAssay Description:Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed