BDBM50026197 Adenosine 5'-triphosphate derivative::CHEMBL3142844

SMILES CO[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1cnc2c(N)ncnc12

InChI Key InChIKey=OARVGPYQJRLYFE-UHFFFAOYSA-N

Data  2 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50026197   

TargetS-adenosylmethionine synthase isoform type-2(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50026197(Adenosine 5'-triphosphate derivative | CHEMBL31428...)
Affinity DataKi:  1.40E+5nMAssay Description:Inhibitory constant against rat kidney Methionine adenosyltransferase II, activity expressed as KiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-1/type-2(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50026197(Adenosine 5'-triphosphate derivative | CHEMBL31428...)
Affinity DataKi:  1.70E+5nMAssay Description:Competitive inhibition of rat methionine adenosyltransferase, activity expressed as KiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50026197(Adenosine 5'-triphosphate derivative | CHEMBL31428...)
Affinity DataIC50: <1.00E+5nMAssay Description:Agonist activity at human P2X7R expressed in HEK293 cells assessed as reduction in YO-PRO-1 iodide dye uptake preincubated for 30 mins followed by YO...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2X purinoceptor 2/3(Homo sapiens (Human))
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50026197(Adenosine 5'-triphosphate derivative | CHEMBL31428...)
Affinity DataIC50: <1.00E+5nMAssay Description:Agonist activity at human P2X2R/P2X3R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followe...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50026197(Adenosine 5'-triphosphate derivative | CHEMBL31428...)
Affinity DataIC50: <1.00E+5nMAssay Description:Agonist activity at human P2X4R expressing HEK293 cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed b...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50026197(Adenosine 5'-triphosphate derivative | CHEMBL31428...)
Affinity DataIC50: <1.00E+5nMAssay Description:Agonist activity at human P2X7R expressing HEK293 cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed b...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2X purinoceptor 2(Homo sapiens (Human))
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50026197(Adenosine 5'-triphosphate derivative | CHEMBL31428...)
Affinity DataIC50: <1.00E+5nMAssay Description:Agonist activity at human P2X2R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed by c...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2X purinoceptor 1(Homo sapiens (Human))
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50026197(Adenosine 5'-triphosphate derivative | CHEMBL31428...)
Affinity DataIC50: <1.00E+5nMAssay Description:Agonist activity at human P2X1R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed by c...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50026197(Adenosine 5'-triphosphate derivative | CHEMBL31428...)
Affinity DataIC50: <1.00E+5nMAssay Description:Agonist activity at human P2X3R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed by c...More data for this Ligand-Target Pair
In DepthDetails PubMed