BDBM50026473 CHEMBL25028::Sulfonylbismethane::dimethyl sulfone::dimethyl sulphone::methylsulfonylmethane::sulfonyldimethane::sulphonylbismethane

SMILES CS(C)(=O)=O

InChI Key InChIKey=HHVIBTZHLRERCL-UHFFFAOYSA-N

Data  4 KI  2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50026473   

TargetCereblon isoform 4(Magnetospirillum gryphiswaldense)
Max Planck Institute for Developmental Biology

Curated by ChEMBL
LigandPNGBDBM50026473(CHEMBL25028 | Sulfonylbismethane | dimethyl sulfon...)
Show SMILES CS(C)(=O)=O
Show InChI InChI=1S/C2H6O2S/c1-5(2,3)4/h1-2H3
Affinity DataKi:  5.69E+6nMAssay Description:Inhibition of MANT-uracil binding to wild type Magnetospirillum gryphiswaldense cereblon isoform 4 by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
TargetCholine O-acetyltransferase(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50026473(CHEMBL25028 | Sulfonylbismethane | dimethyl sulfon...)
Show SMILES CS(C)(=O)=O
Show InChI InChI=1S/C2H6O2S/c1-5(2,3)4/h1-2H3
Affinity DataKi:  2.80E+7nMAssay Description:Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(noncompetitive)More data for this Ligand-Target Pair
TargetProtein cereblon(Homo sapiens (Human))
Max Planck Institute for Developmental Biology

Curated by ChEMBL
LigandPNGBDBM50026473(CHEMBL25028 | Sulfonylbismethane | dimethyl sulfon...)
Show SMILES CS(C)(=O)=O
Show InChI InChI=1S/C2H6O2S/c1-5(2,3)4/h1-2H3
Affinity DataKi:  1.37E+8nMAssay Description:Inhibition of MANT-uracil binding to human CRBN (delta 1 to 315) by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
TargetCholine O-acetyltransferase(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50026473(CHEMBL25028 | Sulfonylbismethane | dimethyl sulfon...)
Show SMILES CS(C)(=O)=O
Show InChI InChI=1S/C2H6O2S/c1-5(2,3)4/h1-2H3
Affinity DataKi:  2.60E+8nMAssay Description:Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(noncompetitive)More data for this Ligand-Target Pair
TargetCereblon isoform 4(Magnetospirillum gryphiswaldense)
Max Planck Institute for Developmental Biology

Curated by ChEMBL
LigandPNGBDBM50026473(CHEMBL25028 | Sulfonylbismethane | dimethyl sulfon...)
Show SMILES CS(C)(=O)=O
Show InChI InChI=1S/C2H6O2S/c1-5(2,3)4/h1-2H3
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of MANT-uracil binding to wild type Magnetospirillum gryphiswaldense cereblon isoform 4 by FRET assayMore data for this Ligand-Target Pair
TargetProtein cereblon(Homo sapiens (Human))
Max Planck Institute for Developmental Biology

Curated by ChEMBL
LigandPNGBDBM50026473(CHEMBL25028 | Sulfonylbismethane | dimethyl sulfon...)
Show SMILES CS(C)(=O)=O
Show InChI InChI=1S/C2H6O2S/c1-5(2,3)4/h1-2H3
Affinity DataIC50: 1.81E+8nMAssay Description:Inhibition of MANT-uracil binding to human CRBN (delta 1 to 315) by FRET assayMore data for this Ligand-Target Pair