BDBM50027431 HYDROXYFASUDIL::Hydroxy-Fasudil

SMILES Oc1nccc2c(cccc12)S(=O)(=O)N1CCCNCC1

InChI Key InChIKey=ZAVGJDAFCZAWSZ-UHFFFAOYSA-N

Data  2 KI  4 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50027431   

TargetRho-associated protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50027431(HYDROXYFASUDIL | Hydroxy-Fasudil)
Affinity DataKi:  150nMAssay Description:Inhibition of human ROCK1 by homogenous luciferase assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50027431(HYDROXYFASUDIL | Hydroxy-Fasudil)
Affinity DataKi:  150nMAssay Description:Inhibition of human leukocytic ROCK1 expressed in insect cells using KKRNRTLSV as substrate after 10 mins by pyruvate kinase/lactate dehydrogenase co...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50027431(HYDROXYFASUDIL | Hydroxy-Fasudil)
Affinity DataIC50:  600nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50027431(HYDROXYFASUDIL | Hydroxy-Fasudil)
Affinity DataIC50:  800nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50027431(HYDROXYFASUDIL | Hydroxy-Fasudil)
Affinity DataIC50:  194nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50027431(HYDROXYFASUDIL | Hydroxy-Fasudil)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed