BDBM50027796 2-(Sulfanilylamino)thiazole::2-(p-Aminobenzenesulfonamido)thiazole::2-(p-Aminobenzenesulphonamido)thiazole::2-Sulfanilamidothiazol::2-Sulfanilamidothiazole::2-Sulfonamidothiazole::4-Amino-N-2-thiazolylbenzenesulfonamide::4-amino-N-1,3-thiazol-2-ylbenzenesulfonamide::CHEMBL437::N(1)-2-Thiazolylsulfanilamide::Sulfanilamidothiazole::Sulfathiazole::Sulphathiazole::cid_5340

SMILES c1cc(ccc1N)S(=O)(=O)Nc2nccs2

InChI Key InChIKey=JNMRHUJNCSQMMB-UHFFFAOYSA-N

Data  6 IC50

PDB links: 4 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50027796   

TargetTranscriptional activator protein LasR(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50027796BDBM50027796(2-Sulfanilamidothiazole | 2-(p-Aminobenzenesulphon...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of LasR in Pseudomonas aeruginosa harboring GFP-fused quorum sensing lasB measured every 15 mins up to 12 hrs by GFP reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTranscriptional activator protein LasR(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50027796BDBM50027796(2-Sulfanilamidothiazole | 2-(p-Aminobenzenesulphon...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of LasR-mediated quorum sensing system in Pseudomonas aeruginosa PAO1 assessed as inhibition of elastase productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetEndothelin-1 receptor(Human)
Prestwick Chemical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50027796BDBM50027796(2-Sulfanilamidothiazole | 2-(p-Aminobenzenesulphon...)
Affinity DataIC50: 6.90E+4nMAssay Description:Inhibitory concentration against Endothelin A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50027796BDBM50027796(2-Sulfanilamidothiazole | 2-(p-Aminobenzenesulphon...)
Affinity DataIC50: 6.90E+4nMAssay Description:Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50027796BDBM50027796(2-Sulfanilamidothiazole | 2-(p-Aminobenzenesulphon...)
Affinity DataIC50: 4.30E+5nMAssay Description:Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMed