BDBM500288 US11021475, Example 52::US11021475, Example 67::US11578058, Compound Reference (BMS-986165)::US11731956, Example control
SMILES CNC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC
InChI Key InChIKey=BZZKEPGENYLQSC-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 500288
TargetNon-receptor tyrosine-protein kinase TYK2 [575-869](Homo sapiens (Human))
Bristol-Myers Squibb
US Patent
Bristol-Myers Squibb
US Patent
Affinity DataEC50: 5.13nMAssay Description:The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...More data for this Ligand-Target Pair
3D Structure (crystal)TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Beijing Innocare Pharma Tech
US Patent
Beijing Innocare Pharma Tech
US Patent
Affinity DataIC50: 5.5nMAssay Description:A binding buffer contains 20 mM Hepes pH 7.5, 150 mM NaCl, 10 mM MgCl, 0.015% Brij35, 2 mM DTT, 0.625 mM EGTA and 100 mM KF. The JH2 domain of TYK2 (...More data for this Ligand-Target Pair
Affinity DataKd: <100nMAssay Description:Similar to the method for TYK2 JH2 binding described above, JAK1 JH2 and JAK2 JH1 domain binding assay was performed using DiscoverX's KINOMEscan...More data for this Ligand-Target Pair
Affinity DataKd: 5.50E+3nMAssay Description:Similar to the method for TYK2 JH2 binding described above, JAK1 JH2 and JAK2 JH1 domain binding assay was performed using DiscoverX's KINOMEscan...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT and 0.01% Brij35 from the kit; a human recombinant ...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Beijing Innocare Pharma Tech
US Patent
Beijing Innocare Pharma Tech
US Patent
Affinity DataIC50: 2.10E+3nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT, 10 nM SEB (Cisbio, Cat. No. 61SEBALB), 0.625 mM EG...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT and 0.01% Brij35 from the kit; a human recombinant ...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Beijing Innocare Pharma Tech
US Patent
Beijing Innocare Pharma Tech
US Patent
Affinity DataIC50: >1.00E+4nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT, 10 nM SEB (Cisbio, Cat. No. 61SEBALB), 0.625 mM EG...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Beijing Innocare Pharma Tech
US Patent
Beijing Innocare Pharma Tech
US Patent
Affinity DataIC50: 5.60nMAssay Description:A binding buffer contains 20 mM Hepes pH 7.5, 150 mM NaCl, 10 mM MgCl, 0.015% Brij35, 2 mM DTT, 0.625 mM EGTA and 100 mM KF. The JH2 domain of TYK2 (...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT and 0.01% Brij35 from the kit; a human recombinant ...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Beijing Innocare Pharma Tech
US Patent
Beijing Innocare Pharma Tech
US Patent
Affinity DataIC50: >1.00E+4nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT, 10 nM SEB (Cisbio, Cat. No. 61SEBALB), 0.625 mM EG...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Beijing Innocare Pharma Tech
US Patent
Beijing Innocare Pharma Tech
US Patent
Affinity DataIC50: 5.70nMAssay Description:A binding buffer contains 20 mM Hepes pH 7.5, 150 mM NaCl, 10 mM MgCl, 0.015% Brij35, 2 mM DTT, 0.625 mM EGTA and 100 mM KF. The JH2 domain of TYK2 (...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT and 0.01% Brij35 from the kit; a human recombinant ...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Beijing Innocare Pharma Tech
US Patent
Beijing Innocare Pharma Tech
US Patent
Affinity DataIC50: >1.00E+4nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT, 10 nM SEB (Cisbio, Cat. No. 61SEBALB), 0.625 mM EG...More data for this Ligand-Target Pair
Affinity DataIC50: 840nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT and 0.01% Brij35 from the kit; a human recombinant ...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Beijing Innocare Pharma Tech
US Patent
Beijing Innocare Pharma Tech
US Patent
Affinity DataIC50: 2.90E+3nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT, 10 nM SEB (Cisbio, Cat. No. 61SEBALB), 0.625 mM EG...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2 [575-869](Homo sapiens (Human))
Bristol-Myers Squibb
US Patent
Bristol-Myers Squibb
US Patent
Affinity DataEC50: 6.53nMAssay Description:The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...More data for this Ligand-Target Pair