BindingDB logo
myBDB logout

BDBM50029726 3'-tert-Butyl-5'-hydroxy-biphenyl-4-carboxylic acid methyl ester::CHEMBL142611

SMILES: COC(=O)c1ccc(cc1)-c1cc(O)cc(c1)C(C)(C)C

InChI Key: InChIKey=NQKNYWRKCVDWQI-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50029726   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50029726
PNG
(3'-tert-Butyl-5'-hydroxy-biphenyl-4-carboxylic aci...)
Show SMILES COC(=O)c1ccc(cc1)-c1cc(O)cc(c1)C(C)(C)C
Show InChI InChI=1S/C18H20O3/c1-18(2,3)15-9-14(10-16(19)11-15)12-5-7-13(8-6-12)17(20)21-4/h5-11,19H,1-4H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
In vitro inhibition of intrinsic tyrosine protein kinase activity of the Epidermal growth factor receptor using tripeptide RR-Src


J Med Chem 38: 4693-703 (1995)


Article DOI: 10.1021/jm00023a009
BindingDB Entry DOI: 10.7270/Q2FX78G6
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50029726
PNG
(3'-tert-Butyl-5'-hydroxy-biphenyl-4-carboxylic aci...)
Show SMILES COC(=O)c1ccc(cc1)-c1cc(O)cc(c1)C(C)(C)C
Show InChI InChI=1S/C18H20O3/c1-18(2,3)15-9-14(10-16(19)11-15)12-5-7-13(8-6-12)17(20)21-4/h5-11,19H,1-4H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Paris

Curated by ChEMBL


Assay Description
In vitro inhibition of EGF-stimulated DNA synthesis of ER 22 cells by following the incorporation of methyl-[3H]thymidine.


J Med Chem 38: 4693-703 (1995)


Article DOI: 10.1021/jm00023a009
BindingDB Entry DOI: 10.7270/Q2FX78G6
More data for this
Ligand-Target Pair