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BDBM50030516 CHEMBL54846::[7-Chloro-1-(2-chloro-benzyl)-1H-quinolin-(4E)-ylidene]-(2,4-dichloro-benzyl)-amine

SMILES: Clc1ccc(C\N=c2/ccn(Cc3ccccc3Cl)c3cc(Cl)ccc23)c(Cl)c1

InChI Key: InChIKey=OYBSFWKFFFMNHU-XAYXJRQQSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50030516   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM50030516
PNG
(CHEMBL54846 | [7-Chloro-1-(2-chloro-benzyl)-1H-qui...)
Show SMILES Clc1ccc(C\N=c2/ccn(Cc3ccccc3Cl)c3cc(Cl)ccc23)c(Cl)c1
Show InChI InChI=1S/C23H16Cl4N2/c24-17-6-5-15(21(27)11-17)13-28-22-9-10-29(14-16-3-1-2-4-20(16)26)23-12-18(25)7-8-19(22)23/h1-12H,13-14H2/b28-22+
PDB
MMDB

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KEGG

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B.MOAD
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 550n/an/an/an/an/an/a



Sanofi Winthrop Inc.

Curated by ChEMBL


Assay Description
Concentration inhibiting [125I]-ChTX (charybdotoxin) binding to N-type potassium channel.


J Med Chem 38: 1877-83 (1995)


Article DOI: 10.1021/jm00011a007
BindingDB Entry DOI: 10.7270/Q2GQ6WSJ
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM50030516
PNG
(CHEMBL54846 | [7-Chloro-1-(2-chloro-benzyl)-1H-qui...)
Show SMILES Clc1ccc(C\N=c2/ccn(Cc3ccccc3Cl)c3cc(Cl)ccc23)c(Cl)c1
Show InChI InChI=1S/C23H16Cl4N2/c24-17-6-5-15(21(27)11-17)13-28-22-9-10-29(14-16-3-1-2-4-20(16)26)23-12-18(25)7-8-19(22)23/h1-12H,13-14H2/b28-22+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 259n/an/an/an/an/an/a



Sanofi Winthrop Inc.

Curated by ChEMBL


Assay Description
Inhibition of outward potassium currents (IKn) in human T-lymphocyte N-type potassium channels.


J Med Chem 38: 1877-83 (1995)


Article DOI: 10.1021/jm00011a007
BindingDB Entry DOI: 10.7270/Q2GQ6WSJ
More data for this
Ligand-Target Pair