BDBM50030765 NPI-2358::Plinabulin
SMILES CC(C)(C)c1[nH]cnc1\C=c1/[nH]c(=O)\c(=C\c2ccccc2)[nH]c1=O
InChI Key InChIKey=UNRCMCRRFYFGFX-TYPNBTCFSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 50030765
TargetTubulin alpha-1A/beta chain(Sus scrofa (Pig))
Tokyo University Of Pharmacy And Life Sciences
Curated by ChEMBL
Tokyo University Of Pharmacy And Life Sciences
Curated by ChEMBL
Affinity DataKd: 1.00E+3nMAssay Description:Binding affinity to porcine tubulin incubated for 1 hr by spectrofluorometryMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKd: 1.06E+3nMAssay Description:Binding affinity to porcine tubulin after 1 hr by spectrofluorometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.81E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.84E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4.23E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 560nMAssay Description:Inhibition of CYP2C9 in human liver microsomes preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 530nMAssay Description:Inhibition of CYP2C9 in human liver microsomes preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataKd: 1.06E+3nMAssay Description:Binding affinity to porcine tubulin after 1 hr by spectrofluorometric analysisMore data for this Ligand-Target Pair
Affinity DataKd: 1.06E+3nMAssay Description:Binding affinity to pig tubulin after 1 hr by fluorescence quenching analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of porcine tubulin polymerization by spectrophotometryMore data for this Ligand-Target Pair