BDBM50031018 4-(5-Oxo-5H-indeno[1,2-c]pyridazin-3-yl)-benzonitrile::4-(5-oxo-5H-indeno[1,2-c]pyridazin-3-yl)benzonitrile::CHEMBL339429

SMILES: O=C1c2ccccc2-c2nnc(cc12)-c1ccc(cc1)C#N

InChI Key: InChIKey=GAYXQEZJMDLSKC-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50031018   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Monoamine oxidase (Rattus norvegicus (rat))	BDBM50031018 (4-(5-Oxo-5H-indeno[1,2-c]pyridazin-3-yl)-benzonitr...) Show SMILES O=C1c2ccccc2-c2nnc(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C18H9N3O/c19-10-11-5-7-12(8-6-11)16-9-15-17(21-20-16)13-3-1-2-4-14(13)18(15)22/h1-9H	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Université de Lausanne Curated by ChEMBL					Assay Description Ability to inhibit Monoamine oxidase A enzyme				J Med Chem 38: 3874-83 (1995) Article DOI: 10.1021/jm00019a018 BindingDB Entry DOI: 10.7270/Q26972M4
					More data for this Ligand-Target Pair
Monoamine Oxidase Type B (MAO-B) (Rattus norvegicus (rat))	BDBM50031018 (4-(5-Oxo-5H-indeno[1,2-c]pyridazin-3-yl)-benzonitr...) Show SMILES O=C1c2ccccc2-c2nnc(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C18H9N3O/c19-10-11-5-7-12(8-6-11)16-9-15-17(21-20-16)13-3-1-2-4-14(13)18(15)22/h1-9H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.19E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of rat brain MAOB				J Med Chem 49: 6264-72 (2006) Article DOI: 10.1021/jm060441e BindingDB Entry DOI: 10.7270/Q2X63P5Q
					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Homo sapiens (Human))	BDBM50031018 (4-(5-Oxo-5H-indeno[1,2-c]pyridazin-3-yl)-benzonitr...) Show SMILES O=C1c2ccccc2-c2nnc(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C18H9N3O/c19-10-11-5-7-12(8-6-11)16-9-15-17(21-20-16)13-3-1-2-4-14(13)18(15)22/h1-9H	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	117	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of human supersomes MAOB				J Med Chem 49: 6264-72 (2006) Article DOI: 10.1021/jm060441e BindingDB Entry DOI: 10.7270/Q2X63P5Q
					More data for this Ligand-Target Pair
Monoamine Oxidase Type B (MAO-B) (Rattus norvegicus (rat))	BDBM50031018 (4-(5-Oxo-5H-indeno[1,2-c]pyridazin-3-yl)-benzonitr...) Show SMILES O=C1c2ccccc2-c2nnc(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C18H9N3O/c19-10-11-5-7-12(8-6-11)16-9-15-17(21-20-16)13-3-1-2-4-14(13)18(15)22/h1-9H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Université de Lausanne Curated by ChEMBL					Assay Description Ability to inhibit Monoamine oxidase B enzyme				J Med Chem 38: 3874-83 (1995) Article DOI: 10.1021/jm00019a018 BindingDB Entry DOI: 10.7270/Q26972M4
					More data for this Ligand-Target Pair