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BDBM50031467 5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE::5-Hydroxy-2-hydroxymethyl-pyran-4-one::CHEMBL287556::Kojic Acid::US9422261, Kojic acid::US9682910, kojic acid

SMILES: OCc1cc(=O)c(O)co1

InChI Key: InChIKey=BEJNERDRQOWKJM-UHFFFAOYSA-N

Data: 8 KI  91 IC50

PDB links: 5 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 98 hits for monomerid = 50031467   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 4.60E+4n/an/an/an/an/an/a



University of Rhode Island

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase using L-tyrosine as a substrate after 30 mins by spectrophotometric method


J Nat Prod 79: 447-50 (2016)


Article DOI: 10.1021/acs.jnatprod.5b00972
BindingDB Entry DOI: 10.7270/Q2G73GNT
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 1.25E+4n/an/an/an/an/an/a



Zhejiang Gongshang University

Curated by ChEMBL


Assay Description
Inhibition of monophenolase activity of mushroom tyrosinase using L-tyrosine as substrate incubated for 10 mins by UV-Visible spectrophotometric anal...


Bioorg Med Chem Lett 26: 3103-8 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.006
BindingDB Entry DOI: 10.7270/Q2JM2CJ8
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 9.50E+3n/an/an/an/an/an/a



Università degli Studi di Cagliari

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosine kinase assessed as oxidation of 0.25 mM L-3,4-dihydroxyphenylalanine


Bioorg Med Chem Lett 19: 36-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.020
BindingDB Entry DOI: 10.7270/Q2445MB2
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 5.37E+4n/an/an/an/an/an/a



Institute for Theoretical Medicine, Inc.

Curated by ChEMBL


Assay Description
Non-competitive inhibition of mushroom tyrosinase


Bioorg Med Chem 22: 6193-200 (2014)


Article DOI: 10.1016/j.bmc.2014.08.027
BindingDB Entry DOI: 10.7270/Q2DV1MG2
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 5.71E+5n/an/an/an/an/an/a



Institute for Theoretical Medicine, Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of tyrosinase in human G-361 cells incubated for 10 mins measured for 2 hrs by MBTH-based spectrophotometry


Bioorg Med Chem 22: 6193-200 (2014)


Article DOI: 10.1016/j.bmc.2014.08.027
BindingDB Entry DOI: 10.7270/Q2DV1MG2
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 1.76E+5n/an/an/an/an/an/a



Tajen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase after 30 mins


J Nat Prod 71: 1930-1933 (2008)


Article DOI: 10.1021/np800564z
BindingDB Entry DOI: 10.7270/Q2SB45TJ
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 2.94E+5n/an/an/an/an/an/a



Tajen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase after 90 mins


J Nat Prod 71: 1930-1933 (2008)


Article DOI: 10.1021/np800564z
BindingDB Entry DOI: 10.7270/Q2SB45TJ
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 2.25E+5n/an/an/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase activity after 90 mins by spectrophotometry


Bioorg Med Chem 17: 4360-6 (2009)


Article DOI: 10.1016/j.bmc.2009.05.019
BindingDB Entry DOI: 10.7270/Q28W3DC3
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 4.38E+5n/an/an/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase activity after 150 mins by spectrophotometry


Bioorg Med Chem 17: 4360-6 (2009)


Article DOI: 10.1016/j.bmc.2009.05.019
BindingDB Entry DOI: 10.7270/Q28W3DC3
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 1.33E+5n/an/an/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase activity after 30 mins by spectrophotometry


Bioorg Med Chem 17: 4360-6 (2009)


Article DOI: 10.1016/j.bmc.2009.05.019
BindingDB Entry DOI: 10.7270/Q28W3DC3
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 6.10E+4n/an/an/an/an/an/a



National Institute of Advanced Industrial Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of catecholase activity of tyrosinase in mouse B16 cells assessed as dopachrome formation


Bioorg Med Chem Lett 19: 4178-82 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.115
BindingDB Entry DOI: 10.7270/Q2BR8S70
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 6.66E+4n/an/an/an/an/an/a



Universiti Putra Malaysia

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase


Eur J Med Chem 44: 3195-200 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.020
BindingDB Entry DOI: 10.7270/Q29S1R35
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 7.22E+5n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase assessed as oxidation of L-DOPA


Bioorg Med Chem Lett 19: 5586-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.041
BindingDB Entry DOI: 10.7270/Q2DF6R8S
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 3.30E+4n/an/an/an/an/an/a



Kyoto Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase


Bioorg Med Chem 17: 6048-53 (2009)


Article DOI: 10.1016/j.bmc.2009.06.057
BindingDB Entry DOI: 10.7270/Q20G3K7R
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 3.00E+4n/an/an/an/an/an/a



Kyoto Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase


Bioorg Med Chem 18: 2337-45 (2010)


Article DOI: 10.1016/j.bmc.2010.01.046
BindingDB Entry DOI: 10.7270/Q2WM1DHZ
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 2.50E+5n/an/an/an/an/an/a



Kyoto Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase assessed as inhibition of melanin production from dopachrome by autoxidation


Bioorg Med Chem 18: 2337-45 (2010)


Article DOI: 10.1016/j.bmc.2010.01.046
BindingDB Entry DOI: 10.7270/Q2WM1DHZ
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 1.40E+5n/an/an/an/an/an/a



Chungnam National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase after 10 mins by spectrophotometry


J Nat Prod 72: 1205-8 (2009)


Article DOI: 10.1021/np900031q
BindingDB Entry DOI: 10.7270/Q2QF8T0K
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 1.63E+4n/an/an/an/an/an/a



Department of Functional Crop

Curated by ChEMBL


Assay Description
Inhibition of monophenolase activity of mushroom tyrosinase using as L-tyrosine substrate by spectrophotometric analysis


Eur J Med Chem 45: 2010-7 (2010)


Article DOI: 10.1016/j.ejmech.2010.01.049
BindingDB Entry DOI: 10.7270/Q2H70FZM
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 9.18E+3n/an/an/an/an/an/a



University Putra Malaysia

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase preincubated for 5 mins before addition of L-DOPA measured after 10 mins


Bioorg Med Chem Lett 20: 3755-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.067
BindingDB Entry DOI: 10.7270/Q290240T
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 3.82E+4n/an/an/an/an/an/a



Pusan National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase


Bioorg Med Chem Lett 20: 4882-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.087
BindingDB Entry DOI: 10.7270/Q26M370Q
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 5.37E+4n/an/an/an/an/an/a



Institute for Theoretical Medicine, Inc.

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase after 15 mins


Bioorg Med Chem 18: 8112-8 (2010)


Article DOI: 10.1016/j.bmc.2010.08.056
BindingDB Entry DOI: 10.7270/Q2JH3MF5
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 8.74E+4n/an/an/an/an/an/a



AmorePacific Corporation

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase after 20 mins by microplate reader analysis


Bioorg Med Chem Lett 20: 6569-71 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.042
BindingDB Entry DOI: 10.7270/Q2QF8T4C
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 1.20E+4n/an/an/an/an/an/a



University of Tokushima

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase


Bioorg Med Chem Lett 20: 7393-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.040
BindingDB Entry DOI: 10.7270/Q26110KT
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 1.85E+4n/an/an/an/an/an/a



Pusan National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase using L-tyrosine as a substrate


Bioorg Med Chem Lett 21: 2445-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.064
BindingDB Entry DOI: 10.7270/Q2PN95XZ
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 5.14E+4n/an/an/an/an/an/a



Kinki University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase after 25 mins by spectrophotometry


Bioorg Med Chem Lett 21: 1983-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.028
BindingDB Entry DOI: 10.7270/Q2T43TCF
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 1.02E+4n/an/an/an/an/an/a



Universidad Nacional de Co£?rdoba

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase preincubated for 10 mins before addition of 1.7 mM L-tyrosine measured after 20 mins by spectrophotometric method


J Nat Prod 74: 158-62 (2011)


Article DOI: 10.1021/np1004664
BindingDB Entry DOI: 10.7270/Q2416XB4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 2.10E+4n/an/an/an/an/an/a



Sun Yat-sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase preincubated for 20 mins


Bioorg Med Chem 19: 1167-71 (2011)


Article DOI: 10.1016/j.bmc.2010.12.051
BindingDB Entry DOI: 10.7270/Q2RJ4JRZ
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 7.40E+3n/an/an/an/an/an/a



Utsunomiya University

Curated by ChEMBL


Assay Description
Inhibition of Tyrosinase


Eur J Med Chem 46: 1374-81 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.065
BindingDB Entry DOI: 10.7270/Q20V8D41
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 3.70E+5n/an/an/an/an/an/a



Institute of Medicinal Plant Development

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase using L-DOPA after 10 mins by ELISA reader


J Nat Prod 74: 1009-14 (2011)


Article DOI: 10.1021/np100900k
BindingDB Entry DOI: 10.7270/Q2TQ61WN
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 1.02E+5n/an/an/an/an/an/a



Universit£ de Grenoble/CNRS

Curated by ChEMBL


Assay Description
Inhibition of diphenolase activity of mushroom tyrosinase using L-DOPA as substrate preincubated for 5 mins by spectroscopic method


Eur J Med Chem 46: 4330-5 (2011)


Article DOI: 10.1016/j.ejmech.2011.07.003
BindingDB Entry DOI: 10.7270/Q2SF2WKC
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 6.94E+4n/an/an/an/an/an/a



Kyung Hee University Skin Biotechnology Center

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase activity using L-tyrosin as substrate after 20 mins


Bioorg Med Chem Lett 21: 7466-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.122
BindingDB Entry DOI: 10.7270/Q2DR2VZK
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 7.04E+4n/an/an/an/an/an/a



Chungnam National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase activity using L-tyrosine as substrate by spectrometric analysis


Bioorg Med Chem Lett 21: 6824-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.024
BindingDB Entry DOI: 10.7270/Q2M9093C
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 3.26E+4n/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase assessed as oxidation of L-dopa by spectrophotometric analysis


J Nat Prod 75: 82-7 (2012)


Article DOI: 10.1021/np2007318
BindingDB Entry DOI: 10.7270/Q21Z44XV
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 2.29E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of tyrosinase enzyme.


Bioorg Med Chem Lett 6: 1303-1308 (1996)


Article DOI: 10.1016/0960-894X(96)00221-1
BindingDB Entry DOI: 10.7270/Q2V1259K
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 2.80E+5n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibitory activity against mushroom tyrosinase (approximate value given)


Bioorg Med Chem Lett 13: 2409-12 (2003)


Article DOI: 10.1016/s0960-894x(03)00395-0
BindingDB Entry DOI: 10.7270/Q2HD7W6H
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 1.67E+4n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibitory activity against tyrosinase


Bioorg Med Chem Lett 16: 324-30 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.085
BindingDB Entry DOI: 10.7270/Q2S75H42
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 1.67E+4n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Eur J Med Chem 42: 1370-81 (2007)


Article DOI: 10.1016/j.ejmech.2007.01.026
BindingDB Entry DOI: 10.7270/Q23R0TP1
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Johns Hopkins University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAAO expressed in HEK293 cell lysate assessed as D-Serine conversion to H2O2 after 20 mins by spectrophotometric anal...


Bioorg Med Chem Lett 23: 3910-3 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.062
BindingDB Entry DOI: 10.7270/Q2K35W2G
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 1.62E+4n/an/an/an/an/an/a



Solapur University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase using L-tyrosine as substrate after 5 mins by UV-spectrophotometric analysis


Bioorg Med Chem 20: 5649-57 (2012)


Article DOI: 10.1016/j.bmc.2012.07.001
BindingDB Entry DOI: 10.7270/Q24X5934
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 1.54E+4n/an/an/an/an/an/a



Solapur University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase using L-DOPA as substrate after 5 mins by UV-spectrophotometric analysis


Bioorg Med Chem 20: 5649-57 (2012)


Article DOI: 10.1016/j.bmc.2012.07.001
BindingDB Entry DOI: 10.7270/Q24X5934
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 7.50E+4n/an/an/an/an/an/a



Mayoly Spindler S.A.

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase


Bioorg Med Chem Lett 18: 3607-10 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.079
BindingDB Entry DOI: 10.7270/Q22F7PB4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 2.30E+4n/an/an/an/an/an/a



Sun Yat-sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase


Bioorg Med Chem 16: 1096-102 (2008)


Article DOI: 10.1016/j.bmc.2007.10.102
BindingDB Entry DOI: 10.7270/Q2RF5VWT
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 1.50E+7n/an/an/an/an/an/a



Univ. Grenoble-Alpes/CNRS

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase in human MNT1 cells assessed as suppression of melanin biosynthesis measured after 96 hrs


ACS Med Chem Lett 8: 55-60 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00369
BindingDB Entry DOI: 10.7270/Q24F1SQN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 2.80E+6n/an/an/an/an/an/a



Univ. Grenoble-Alpes/CNRS

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase in human MNT1 cell lysate pretreated prior to addition of L-DOPA as substrate measured after 3 hrs


ACS Med Chem Lett 8: 55-60 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00369
BindingDB Entry DOI: 10.7270/Q24F1SQN
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 8.33E+3n/an/an/an/an/an/a



Universit£ degli Studi di Cagliari

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase after 10 mins by L-DOPA oxidation assay


Bioorg Med Chem Lett 20: 6138-40 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.018
BindingDB Entry DOI: 10.7270/Q2N87BSC
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 6.94E+4n/an/an/an/an/an/a



Kaohsiung Medical University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase after 30 mins by spectrophotometric analysis


Bioorg Med Chem 18: 5241-7 (2010)


Article DOI: 10.1016/j.bmc.2010.05.045
BindingDB Entry DOI: 10.7270/Q2JS9RFV
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
UniProtKB/SwissProt

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Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Hunan University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity assessed as reduction in dopachrome formation using L-DOPA as substrate preincubated for 20 mi...


Bioorg Med Chem Lett 27: 530-532 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.027
BindingDB Entry DOI: 10.7270/Q26M392F
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
UniProtKB/SwissProt

GoogleScholar
Purchase

CHEBI
CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.00E+6n/an/an/an/an/an/a



Universidad Nacional de C£rdoba

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase in mouse B16 cells assessed as reduction in melanin production measured after 24 hrs


Bioorg Med Chem Lett 27: 1789-1794 (2017)


Article DOI: 10.1016/j.bmcl.2017.02.058
BindingDB Entry DOI: 10.7270/Q2MW2KDB
More data for this
Ligand-Target Pair
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