BDBM50031706 4-Guanidino-benzoic acid 4-dimethylcarbamoylmethoxycarbonylmethyl-phenyl ester; compound with methanesulfonic acid::CHEMBL85164::Camostat::med.21724, Compound 18

SMILES [#6]-[#7](-[#6])-[#6](=O)-[#6]-[#8]-[#6](=O)-[#6]-c1ccc(-[#8]-[#6](=O)-c2ccc(cc2)\[#7]=[#6](/[#7])-[#7])cc1

InChI Key InChIKey=XASIMHXSUQUHLV-UHFFFAOYSA-N

Data  6 KI  10 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50031706   

TargetSerine protease hepsin(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50031706(4-Guanidino-benzoic acid 4-dimethylcarbamoylmethox...)
Affinity DataKi:  4.20nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane protease serine 6(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50031706(4-Guanidino-benzoic acid 4-dimethylcarbamoylmethox...)
Affinity DataKi:  5.60nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease hepsin(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50031706(4-Guanidino-benzoic acid 4-dimethylcarbamoylmethox...)
Affinity DataKi:  5.80nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50031706(4-Guanidino-benzoic acid 4-dimethylcarbamoylmethox...)
Affinity DataKi:  621nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50031706(4-Guanidino-benzoic acid 4-dimethylcarbamoylmethox...)
Affinity DataKi: >1.00E+4nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50031706(4-Guanidino-benzoic acid 4-dimethylcarbamoylmethox...)
Affinity DataKi: >1.00E+4nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin G(Homo sapiens (Human))
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50031706(4-Guanidino-benzoic acid 4-dimethylcarbamoylmethox...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to inhibit enzymatic cleavage of the chromogenic substrate (MeO-Suc-Ala-Ala-Pro-Met-pNA) for cathepsin G in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Institut Pasteur Korea

LigandPNGBDBM50031706(4-Guanidino-benzoic acid 4-dimethylcarbamoylmethox...)
Affinity DataIC50: >5.00E+4nMAssay Description:Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane protease serine 2(Homo sapiens (Human))
University Of Bonn

LigandPNGBDBM50031706(4-Guanidino-benzoic acid 4-dimethylcarbamoylmethox...)
Affinity DataEC50:  1.00E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane protease serine 2(Homo sapiens (Human))
University Of Bonn

LigandPNGBDBM50031706(4-Guanidino-benzoic acid 4-dimethylcarbamoylmethox...)
Affinity DataIC50:  18nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Institut Pasteur Korea

LigandPNGBDBM50031706(4-Guanidino-benzoic acid 4-dimethylcarbamoylmethox...)
Affinity DataEC50:  11nMAssay Description:Intracellular dose response (EC50 values) for selected compounds against SARS-CoV-2 were determined by pre-treating Calu-3 cells for three hr with se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50031706(4-Guanidino-benzoic acid 4-dimethylcarbamoylmethox...)
Affinity DataIC50:  3.16E+4nMAssay Description:Concentration required to inhibit enzymatic cleavage of the chromogenic substrate (H-D-Phe-Pip-Arg-pNA) thrombin in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50031706(4-Guanidino-benzoic acid 4-dimethylcarbamoylmethox...)
Affinity DataIC50:  50.6nMAssay Description:Concentration required to inhibit enzymatic cleavage of the chromogenic substrate (Boc-Phe-Ser-Arg-AMC) for trypsin in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50031706(4-Guanidino-benzoic acid 4-dimethylcarbamoylmethox...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to inhibit enzymatic cleavage of the chromogenic substrate (Suc-Ala-Ala-Pro-Phe-pNA) for chymotrypsin in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Rattus norvegicus)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50031706(4-Guanidino-benzoic acid 4-dimethylcarbamoylmethox...)
Affinity DataIC50:  2.62E+3nMAssay Description:Concentration required to inhibit enzymatic cleavage of the chromogenic substrate (H-D-Val-Leu-Lys-pNA) for plasmin in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50031706(4-Guanidino-benzoic acid 4-dimethylcarbamoylmethox...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to inhibit enzymatic cleavage of the chromogenic substrate (MeO-Suc-Ala-Ala-Pro-Val-pNA) for sputum elastase in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-1(Homo sapiens (Human))
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50031706(4-Guanidino-benzoic acid 4-dimethylcarbamoylmethox...)
Affinity DataIC50:  3.41E+4nMAssay Description:Concentration required to inhibit enzymatic cleavage of the chromogenic substrate (H-D-Val-Leu-Arg-pNA) for pancreatic kallikrein in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-1(Homo sapiens (Human))
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50031706(4-Guanidino-benzoic acid 4-dimethylcarbamoylmethox...)
Affinity DataIC50:  1.48E+3nMAssay Description:Concentration required to inhibit enzymatic cleavage of the chromogenic substrate (H-D-Pro-Phe-Arg-pNA) for plasma kallikrein in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed