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BDBM50032613 CHEMBL78308::[5-Fluoro-1-(2-morpholin-4-yl-ethyl)-1H-indol-3-yl]-naphthalen-1-yl-methanone

SMILES: Fc1ccc2n(CCN3CCOCC3)cc(C(=O)c3cccc4ccccc34)c2c1

InChI Key: InChIKey=YKAFJPALAGTJCW-UHFFFAOYSA-N

Data: 2 KI  1 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50032613   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor


(Rattus norvegicus (rat))
BDBM50032613
PNG
(CHEMBL78308 | [5-Fluoro-1-(2-morpholin-4-yl-ethyl)...)
Show SMILES Fc1ccc2n(CCN3CCOCC3)cc(C(=O)c3cccc4ccccc34)c2c1
Show InChI InChI=1S/C25H23FN2O2/c26-19-8-9-24-22(16-19)23(17-28(24)11-10-27-12-14-30-15-13-27)25(29)21-7-3-5-18-4-1-2-6-20(18)21/h1-9,16-17H,10-15H2
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.63E+7n/an/an/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Cannabinoid receptor 1 binding affinity by measuring its ability to displace [3H]WIN-55212-2 in rat forebrain membranes


J Med Chem 41: 4521-32 (1998)


Article DOI: 10.1021/jm980305c
BindingDB Entry DOI: 10.7270/Q2XD14F0
More data for this
Ligand-Target Pair
Cannabinoid receptor


(Rattus norvegicus (rat))
BDBM50032613
PNG
(CHEMBL78308 | [5-Fluoro-1-(2-morpholin-4-yl-ethyl)...)
Show SMILES Fc1ccc2n(CCN3CCOCC3)cc(C(=O)c3cccc4ccccc34)c2c1
Show InChI InChI=1S/C25H23FN2O2/c26-19-8-9-24-22(16-19)23(17-28(24)11-10-27-12-14-30-15-13-27)25(29)21-7-3-5-18-4-1-2-6-20(18)21/h1-9,16-17H,10-15H2
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PubMed
3.63E+7n/an/an/an/an/an/an/an/a



Institute of Bioorganic & Petroleum Chemistry

Curated by ChEMBL


Assay Description
Binding affinity at cannabinoid receptor 1 using rat brain membranes


J Med Chem 44: 2411-20 (2001)


Article DOI: 10.1021/jm010858e
BindingDB Entry DOI: 10.7270/Q2GT5QXX
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50032613
PNG
(CHEMBL78308 | [5-Fluoro-1-(2-morpholin-4-yl-ethyl)...)
Show SMILES Fc1ccc2n(CCN3CCOCC3)cc(C(=O)c3cccc4ccccc34)c2c1
Show InChI InChI=1S/C25H23FN2O2/c26-19-8-9-24-22(16-19)23(17-28(24)11-10-27-12-14-30-15-13-27)25(29)21-7-3-5-18-4-1-2-6-20(18)21/h1-9,16-17H,10-15H2
PDB

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n/an/a 35n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.


J Med Chem 38: 3094-105 (1995)


Article DOI: 10.1021/jm00016a013
BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair