BDBM50033115 (5aS,11bR)-2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyclopenta[c]phenanthrene-9,10-diol; hydrochloride::CHEMBL2115374::CHEMBL544814

SMILES CCCc1cc2[C@@H]3[C@H](CCc4cc(O)c(O)cc34)NCc2s1

InChI Key InChIKey=REHAKLRYABHSQJ-KBXCAEBGSA-N

Data  4 KI  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50033115   

TargetD(1A) dopamine receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50033115((5aS,11bR)-2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thi...)
Affinity DataKi:  640nMAssay Description:In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50033115((5aS,11bR)-2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thi...)
Affinity DataKi:  3.05E+3nMAssay Description:Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50033115((5aS,11bR)-2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thi...)
Affinity DataKi:  4.02E+3nMAssay Description:Binding affinity against cloned human Dopamine receptor D2 using [3H]spiperone as radioligand transfected in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50033115((5aS,11bR)-2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thi...)
Affinity DataKi:  5.40E+3nMAssay Description:In vitro binding affinity against Dopamine receptor D2 like from rat caudate membrane using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50033115((5aS,11bR)-2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thi...)
Affinity DataEC50: >1.00E+4nMAssay Description:Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1) dopamine receptor(Carassius auratus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50033115((5aS,11bR)-2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thi...)
Affinity DataEC50:  2.70E+3nMAssay Description:Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50033115((5aS,11bR)-2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thi...)
Affinity DataEC50:  1.70E+3nMAssay Description:Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1) dopamine receptor(Carassius auratus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50033115((5aS,11bR)-2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thi...)
Affinity DataEC50:  2.70E+3nMAssay Description:Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed