BDBM50034259 3-Benzo[1,3]dioxol-5-yl-5-hydroxy-4-(4-methoxy-benzyl)-5-(4-methoxy-phenyl)-5H-furan-2-one::CHEMBL11115

SMILES COc1ccc(CC2=C(C(=O)OC2(O)c2ccc(OC)cc2)c2ccc3OCOc3c2)cc1

InChI Key InChIKey=SUKHVLAHDGZTPC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50034259   

TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034259(3-Benzo[1,3]dioxol-5-yl-5-hydroxy-4-(4-methoxy-ben...)
Affinity DataIC50:  9nMAssay Description:Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034259(3-Benzo[1,3]dioxol-5-yl-5-hydroxy-4-(4-methoxy-ben...)
Affinity DataIC50:  1.55E+3nMAssay Description:Tested for antagonistic activity against Endothelin B receptor in the humans (CHO expressed).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034259(3-Benzo[1,3]dioxol-5-yl-5-hydroxy-4-(4-methoxy-ben...)
Affinity DataIC50:  1.80nMAssay Description:Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034259(3-Benzo[1,3]dioxol-5-yl-5-hydroxy-4-(4-methoxy-ben...)
Affinity DataIC50:  220nMAssay Description:Tested for antagonistic activity against Endothelin B receptor in the rat cerebellum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034259(3-Benzo[1,3]dioxol-5-yl-5-hydroxy-4-(4-methoxy-ben...)
Affinity DataIC50:  1.55E+3nMAssay Description:Binding affinity against human cloned Endothelin B receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034259(3-Benzo[1,3]dioxol-5-yl-5-hydroxy-4-(4-methoxy-ben...)
Affinity DataIC50:  1.80nMAssay Description:Antagonistic activity against human Endothelin A receptor expressed in LtKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed