BindingDB PrimarySearch

BDBM86708 CAS_146714-97-8::CHEMBL31354::CHEMBL514874::CHEMBL537403::NSC_104911::WAY 100,635

SMILES: COc1ccccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccn2)CC1

InChI Key: InChIKey=SBPRIAGPYFYCRT-UHFFFAOYSA-N

Data: 107 KI 12 IC50 1 Kd 2 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 122 hits for monomerid = 86708
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histamine H2 Receptor (Homo sapiens (Human))	BDBM86708 (CAS_146714-97-8 \| CHEMBL31354 \| CHEMBL514874 \| CHE...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by PDSP K_i Database									Psychopharmacology (Berl) 188: 244-51 (2006) Article DOI: 10.1007/s00213-006-0490-4 BindingDB Entry DOI: 10.7270/Q2HX1B8P
Purdue University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
HRH3 (GUINEA PIG)	BDBM86708 (CAS_146714-97-8 \| CHEMBL31354 \| CHEMBL514874 \| CHE...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by PDSP K_i Database									Psychopharmacology (Berl) 188: 244-51 (2006) Article DOI: 10.1007/s00213-006-0490-4 BindingDB Entry DOI: 10.7270/Q2HX1B8P
Purdue University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM86708 (CAS_146714-97-8 \| CHEMBL31354 \| CHEMBL514874 \| CHE...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by PDSP K_i Database									Psychopharmacology (Berl) 188: 244-51 (2006) Article DOI: 10.1007/s00213-006-0490-4 BindingDB Entry DOI: 10.7270/Q2HX1B8P
Purdue University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Delta-type opioid receptor (Homo sapiens (Human))	BDBM86708 (CAS_146714-97-8 \| CHEMBL31354 \| CHEMBL514874 \| CHE...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by PDSP K_i Database									Psychopharmacology (Berl) 188: 244-51 (2006) Article DOI: 10.1007/s00213-006-0490-4 BindingDB Entry DOI: 10.7270/Q2HX1B8P
Purdue University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Cannabinoid receptor 1/Mu-type opioid receptor (Homo sapiens (Human))	BDBM86708 (CAS_146714-97-8 \| CHEMBL31354 \| CHEMBL514874 \| CHE...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by PDSP K_i Database									Psychopharmacology (Berl) 188: 244-51 (2006) Article DOI: 10.1007/s00213-006-0490-4 BindingDB Entry DOI: 10.7270/Q2HX1B8P
Purdue University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7) (Homo sapiens (Human))	BDBM86708 (CAS_146714-97-8 \| CHEMBL31354 \| CHEMBL514874 \| CHE...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
VU University Medical Center Curated by ChEMBL					Assay Description Inhibition of 5HT7 receptor				J Med Chem 54: 3480-91 (2011) Article DOI: 10.1021/jm1009956 BindingDB Entry DOI: 10.7270/Q2HX1D1C
VU University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7) (Homo sapiens (Human))	BDBM86708 (CAS_146714-97-8 \| CHEMBL31354 \| CHEMBL514874 \| CHE...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
VU University Medical Center Curated by ChEMBL					Assay Description Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay				Eur J Med Chem 46: 5728-35 (2011) Article DOI: 10.1016/j.ejmech.2011.06.023 BindingDB Entry DOI: 10.7270/Q2542P0K
VU University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Rattus norvegicus (rat))	BDBM86708 (CAS_146714-97-8 \| CHEMBL31354 \| CHEMBL514874 \| CHE...) Show SMILES Show InChI	KEGG GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal homogenates				J Med Chem 37: 1406-7 (1994) Article DOI: 10.1021/jm00036a003 BindingDB Entry DOI: 10.7270/Q29Z95JQ
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A) (Homo sapiens (Human))	BDBM86708 (CAS_146714-97-8 \| CHEMBL31354 \| CHEMBL514874 \| CHE...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.04	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding				J Med Chem 51: 6980-7004 (2008) Article DOI: 10.1021/jm8007097 BindingDB Entry DOI: 10.7270/Q2TT4RWM
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A) (Homo sapiens (Human))	BDBM86708 (CAS_146714-97-8 \| CHEMBL31354 \| CHEMBL514874 \| CHE...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Adamed Ltd. Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5-HT1A receptor assessed as inhibition of 8-OH-DPAT-induced response by cellular dielectric spectroscopy				J Med Chem 57: 4543-57 (2014) Article DOI: 10.1021/jm401895u BindingDB Entry DOI: 10.7270/Q2N29ZHX
Adamed Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Rattus norvegicus (rat))	BDBM86708 (CAS_146714-97-8 \| CHEMBL31354 \| CHEMBL514874 \| CHE...) Show SMILES Show InChI	KEGG GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description In vitro binding affinity for 5-hydroxytryptamine 1A receptor was determined by measuring specific inhibition of [125I]-binding to rat hippocampal me...				J Med Chem 41: 157-66 (1998) Article DOI: 10.1021/jm970296s BindingDB Entry DOI: 10.7270/Q2TX3DH6
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Rattus norvegicus (rat))	BDBM86708 (CAS_146714-97-8 \| CHEMBL31354 \| CHEMBL514874 \| CHE...) Show SMILES Show InChI	KEGG GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.370	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description In vitro affinity against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in rat hippocampus				J Med Chem 43: 432-9 (2000) Article DOI: 10.1021/jm991088y BindingDB Entry DOI: 10.7270/Q2513XFN
University of Groningen Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM86708 (CAS_146714-97-8 \| CHEMBL31354 \| CHEMBL514874 \| CHE...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition concentration against [3H]-5-HT uptake by human serotonin transporter in JAR cells				J Med Chem 47: 3823-42 (2004) Article DOI: 10.1021/jm0304010 BindingDB Entry DOI: 10.7270/Q2S46RDW
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A) (Homo sapiens (Human))	BDBM86708 (CAS_146714-97-8 \| CHEMBL31354 \| CHEMBL514874 \| CHE...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.10	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Effective concentration against human 5-hydroxytryptamine 1A receptor using cAMP as radioligand in CHO cells				J Med Chem 47: 3823-42 (2004) Article DOI: 10.1021/jm0304010 BindingDB Entry DOI: 10.7270/Q2S46RDW
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A) (Homo sapiens (Human))	BDBM86708 (CAS_146714-97-8 \| CHEMBL31354 \| CHEMBL514874 \| CHE...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.10	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Effective concentration against binding of radioligand [35]GTPgammaS in CHO cells expressing human 5-hydroxytryptamine 1A receptor				J Med Chem 47: 3823-42 (2004) Article DOI: 10.1021/jm0304010 BindingDB Entry DOI: 10.7270/Q2S46RDW
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A) (Homo sapiens (Human))	BDBM86708 (CAS_146714-97-8 \| CHEMBL31354 \| CHEMBL514874 \| CHE...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Collegium Medicum Curated by ChEMBL					Assay Description Antagonist activity against human recombinant 5-HT1A receptor expressed in CHOK1 cells assessed as reduction in serotonin-induced increase in intrace...				Eur J Med Chem 92: 221-35 (2015) Article DOI: 10.1016/j.ejmech.2014.12.045 BindingDB Entry DOI: 10.7270/Q2Q241XV
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A) (Homo sapiens (Human))	BDBM86708 (CAS_146714-97-8 \| CHEMBL31354 \| CHEMBL514874 \| CHE...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.910	n/a	n/a	n/a	n/a	n/a	n/a
VU University Medical Center Curated by ChEMBL					Assay Description Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in HEK293 EBNA cells after 1 hr by liquid scintillation counting				J Med Chem 54: 3480-91 (2011) Article DOI: 10.1021/jm1009956 BindingDB Entry DOI: 10.7270/Q2HX1D1C
VU University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A) (Homo sapiens (Human))	BDBM86708 (CAS_146714-97-8 \| CHEMBL31354 \| CHEMBL514874 \| CHE...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.910	n/a	n/a	n/a	n/a	n/a	n/a
VU University Medical Center Curated by ChEMBL					Assay Description Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HEK293 EBNA cells after 2 hrs by liquid scintillation counting				Eur J Med Chem 46: 5728-35 (2011) Article DOI: 10.1016/j.ejmech.2011.06.023 BindingDB Entry DOI: 10.7270/Q2542P0K
VU University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Rattus norvegicus (rat))	BDBM86708 (CAS_146714-97-8 \| CHEMBL31354 \| CHEMBL514874 \| CHE...) Show SMILES Show InChI	KEGG GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description In vitro binding affinity to 5-hydroxytryptamine 1A receptor using [125I](R)-(+)-trans-8-OH-PIPAT as radioligand in rat hippocampal homogenate				J Med Chem 37: 4572-5 (1995) Article DOI: 10.1021/jm00052a018 BindingDB Entry DOI: 10.7270/Q24X58F6
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A) (Homo sapiens (Human))	BDBM86708 (CAS_146714-97-8 \| CHEMBL31354 \| CHEMBL514874 \| CHE...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.40	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cells				J Med Chem 48: 3467-70 (2005) Article DOI: 10.1021/jm049493z BindingDB Entry DOI: 10.7270/Q2S1838Z
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A) (Homo sapiens (Human))	BDBM86708 (CAS_146714-97-8 \| CHEMBL31354 \| CHEMBL514874 \| CHE...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.06	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production				J Med Chem 49: 4785-9 (2006) Article DOI: 10.1021/jm060218h BindingDB Entry DOI: 10.7270/Q261114D
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A) (Homo sapiens (Human))	BDBM86708 (CAS_146714-97-8 \| CHEMBL31354 \| CHEMBL514874 \| CHE...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated incre...				J Med Chem 53: 4066-84 (2010) Article DOI: 10.1021/jm1000908 BindingDB Entry DOI: 10.7270/Q28P60P7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair

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