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BDBM50035960 5-Trifluoromethyl-1-[4-(3-trifluoromethyl-phenyl)-thiazol-2-yl]-1H-pyrazole-4-carboxylic acid (3-amino-propyl)-amide; hydrochloride::CHEMBL543666

SMILES: NCCCNC(=O)c1cnn(-c2nc(cs2)-c2cccc(c2)C(F)(F)F)c1C(F)(F)F

InChI Key: InChIKey=WQOLAFVZLZRKGA-UHFFFAOYSA-N

Data: 3 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50035960   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Integrin alpha-IIb/beta-3


(Homo sapiens (Human))
BDBM50035960
PNG
(5-Trifluoromethyl-1-[4-(3-trifluoromethyl-phenyl)-...)
Show SMILES NCCCNC(=O)c1cnn(-c2nc(cs2)-c2cccc(c2)C(F)(F)F)c1C(F)(F)F
Show InChI InChI=1S/C18H15F6N5OS/c19-17(20,21)11-4-1-3-10(7-11)13-9-31-16(28-13)29-14(18(22,23)24)12(8-27-29)15(30)26-6-2-5-25/h1,3-4,7-9H,2,5-6,25H2,(H,26,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.70E+3n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of arachidonic acid-induced platelet aggregation


J Med Chem 38: 34-41 (1995)


Article DOI: 10.1021/jm00001a008
BindingDB Entry DOI: 10.7270/Q29G5NG8
More data for this
Ligand-Target Pair
Integrin alpha-IIb/beta-3


(Homo sapiens (Human))
BDBM50035960
PNG
(5-Trifluoromethyl-1-[4-(3-trifluoromethyl-phenyl)-...)
Show SMILES NCCCNC(=O)c1cnn(-c2nc(cs2)-c2cccc(c2)C(F)(F)F)c1C(F)(F)F
Show InChI InChI=1S/C18H15F6N5OS/c19-17(20,21)11-4-1-3-10(7-11)13-9-31-16(28-13)29-14(18(22,23)24)12(8-27-29)15(30)26-6-2-5-25/h1,3-4,7-9H,2,5-6,25H2,(H,26,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.23E+4n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]fibrinogen binding to human Fibrinogen Receptor.


J Med Chem 38: 34-41 (1995)


Article DOI: 10.1021/jm00001a008
BindingDB Entry DOI: 10.7270/Q29G5NG8
More data for this
Ligand-Target Pair
Integrin alpha-IIb/beta-3


(Homo sapiens (Human))
BDBM50035960
PNG
(5-Trifluoromethyl-1-[4-(3-trifluoromethyl-phenyl)-...)
Show SMILES NCCCNC(=O)c1cnn(-c2nc(cs2)-c2cccc(c2)C(F)(F)F)c1C(F)(F)F
Show InChI InChI=1S/C18H15F6N5OS/c19-17(20,21)11-4-1-3-10(7-11)13-9-31-16(28-13)29-14(18(22,23)24)12(8-27-29)15(30)26-6-2-5-25/h1,3-4,7-9H,2,5-6,25H2,(H,26,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of collagen-induced platelet aggregation


J Med Chem 38: 34-41 (1995)


Article DOI: 10.1021/jm00001a008
BindingDB Entry DOI: 10.7270/Q29G5NG8
More data for this
Ligand-Target Pair