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BDBM50035967 5-Trifluoromethyl-1-[4-(3-trifluoromethyl-phenyl)-thiazol-2-yl]-1H-pyrazole-4-carboxylic acid (3-carbamimidoyl-propyl)-amide; hydrochloride::CHEMBL557202

SMILES: NC(=N)CCCNC(=O)c1cnn(-c2nc(cs2)-c2cccc(c2)C(F)(F)F)c1C(F)(F)F

InChI Key: InChIKey=YIHPBANAYPNMTP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50035967   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Integrin alpha-IIb/beta-3


(Homo sapiens (Human))
BDBM50035967
PNG
(5-Trifluoromethyl-1-[4-(3-trifluoromethyl-phenyl)-...)
Show SMILES NC(=N)CCCNC(=O)c1cnn(-c2nc(cs2)-c2cccc(c2)C(F)(F)F)c1C(F)(F)F
Show InChI InChI=1S/C19H16F6N6OS/c20-18(21,22)11-4-1-3-10(7-11)13-9-33-17(30-13)31-15(19(23,24)25)12(8-29-31)16(32)28-6-2-5-14(26)27/h1,3-4,7-9H,2,5-6H2,(H3,26,27)(H,28,32)
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Similars

Article
PubMed
n/an/a 2.30E+4n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]fibrinogen binding to human Fibrinogen Receptor.


J Med Chem 38: 34-41 (1995)


Article DOI: 10.1021/jm00001a008
BindingDB Entry DOI: 10.7270/Q29G5NG8
More data for this
Ligand-Target Pair