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BDBM50036631 CHEMBL3352836

SMILES: COc1ccc(CNc2nc(ncc2C(=O)NCCCO)N2CCC[C@H]2CO)cc1Cl

InChI Key: InChIKey=RECLIWYSXXJJLO-GGYSOQFKNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50036631   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Canis lupus familiaris)
BDBM50036631
PNG
(CHEMBL3352836)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCCCO)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1/C21H28ClN5O4/c1-31-18-6-5-14(10-17(18)22)11-24-19-16(20(30)23-7-3-9-28)12-25-21(26-19)27-8-2-4-15(27)13-29/h5-6,10,12,15,28-29H,2-4,7-9,11,13H2,1H3,(H,23,30)(H,24,25,26)/t15-/s2
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PC cid
PC sid
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Similars

Article
PubMed
n/an/a 6.60n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis


Bioorg Med Chem Lett 24: 5460-5 (2015)


Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W
More data for this
Ligand-Target Pair