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BDBM50036755 CHEMBL556048::N-[6-(2-Guanidino-thiazol-4-yl)-pyridin-2-ylmethyl]-acetamide; hydrochloride

SMILES: [#6]-[#6](=O)-[#7]-[#6]-c1cccc(n1)-c1csc(\[#7]=[#6](/[#7])-[#7])n1

InChI Key: InChIKey=AOCMLOWDFAEKJE-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50036755   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50036755
PNG
(CHEMBL556048 | N-[6-(2-Guanidino-thiazol-4-yl)-pyr...)
Show SMILES CC(=O)NCc1cccc(n1)-c1csc(N=C(N)N)n1
Show InChI InChI=1S/C12H14N6OS/c1-7(19)15-5-8-3-2-4-9(16-8)10-6-20-12(17-10)18-11(13)14/h2-4,6H,5H2,1H3,(H,15,19)(H4,13,14,17,18)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company

Curated by ChEMBL


Assay Description
Compound was tested for H2 receptor antagonistic activity against histamine stimulated chronotropic response in isolated guinea pig right atrium


J Med Chem 37: 57-66 (1994)


Article DOI: 10.1021/jm00027a007
BindingDB Entry DOI: 10.7270/Q2FN16TT
More data for this
Ligand-Target Pair