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BDBM50037402 8-Amino-2-(4-amino-phenyl)-5-hydroxy-chromen-4-one::CHEMBL114578

SMILES: Nc1ccc(cc1)-c1cc(=O)c2c(O)ccc(N)c2o1

InChI Key: InChIKey=NHSMVSTXNNRRAC-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50037402   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50037402
PNG
(8-Amino-2-(4-amino-phenyl)-5-hydroxy-chromen-4-one...)
Show SMILES Nc1ccc(cc1)-c1cc(=O)c2c(O)ccc(N)c2o1
Show InChI InChI=1S/C15H12N2O3/c16-9-3-1-8(2-4-9)13-7-12(19)14-11(18)6-5-10(17)15(14)20-13/h1-7,18H,16-17H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Inhibition of in vitro activity of EGFr enzyme from A431 cells in presence of 5 uM ATP


J Med Chem 37: 3353-62 (1994)


Article DOI: 10.1021/jm00046a020
BindingDB Entry DOI: 10.7270/Q2D21WNP
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50037402
PNG
(8-Amino-2-(4-amino-phenyl)-5-hydroxy-chromen-4-one...)
Show SMILES Nc1ccc(cc1)-c1cc(=O)c2c(O)ccc(N)c2o1
Show InChI InChI=1S/C15H12N2O3/c16-9-3-1-8(2-4-9)13-7-12(19)14-11(18)6-5-10(17)15(14)20-13/h1-7,18H,16-17H2
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.26E+5n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
In vitro inhibition of protein-tyrosine activity of p56lck enzyme in presence of 50 uM ATP


J Med Chem 37: 3353-62 (1994)


Article DOI: 10.1021/jm00046a020
BindingDB Entry DOI: 10.7270/Q2D21WNP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50037402
PNG
(8-Amino-2-(4-amino-phenyl)-5-hydroxy-chromen-4-one...)
Show SMILES Nc1ccc(cc1)-c1cc(=O)c2c(O)ccc(N)c2o1
Show InChI InChI=1S/C15H12N2O3/c16-9-3-1-8(2-4-9)13-7-12(19)14-11(18)6-5-10(17)15(14)20-13/h1-7,18H,16-17H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Inhibition of in vitro protein-tyrosine kinase activity of p60v-src enzyme in presence of 5 uM ATP.


J Med Chem 37: 3353-62 (1994)


Article DOI: 10.1021/jm00046a020
BindingDB Entry DOI: 10.7270/Q2D21WNP
More data for this
Ligand-Target Pair