BDBM50037435 CHEMBL16724::[4-(1,3-Diallyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetic acid

SMILES OC(=O)COc1ccc(cc1)-c1nc2n(CC=C)c(=O)n(CC=C)c(=O)c2[nH]1

InChI Key InChIKey=CZKQVHBXRSZWAF-UHFFFAOYSA-N

Data  10 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50037435   

TargetAdenosine receptor A2b(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50037435([4-(1,3-Diallyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-pu...)
Affinity DataKi:  141nMAssay Description:Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50037435([4-(1,3-Diallyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-pu...)
Affinity DataKi:  756nMAssay Description:Antagonist activity against adenosine A1 receptor in rat brain membrane in presence of [3H]R-PIA radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50037435([4-(1,3-Diallyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-pu...)
Affinity DataKi:  756nMAssay Description:Displacement of [3H]PIA from adenosine A1 receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50037435([4-(1,3-Diallyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-pu...)
Affinity DataKi:  816nMAssay Description:Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50037435([4-(1,3-Diallyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-pu...)
Affinity DataKi:  1.66E+3nMAssay Description:Antagonist activity against recombinant human adenosine A1 receptor expressed in HEK293 cells in presence of [125I]IABA radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50037435([4-(1,3-Diallyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-pu...)
Affinity DataKi:  2.37E+3nMAssay Description:Antagonist activity against recombinant human adenosine A2A receptor expressed in HEK293 cells in presence of [125I]iodo-ZM-241385 radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50037435([4-(1,3-Diallyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-pu...)
Affinity DataKi:  4.29E+3nMAssay Description:Antagonist activity against adenosine A2A receptor in rat striatal membrane in presence of [3H]CGS-21680 radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50037435([4-(1,3-Diallyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-pu...)
Affinity DataKi:  4.29E+3nMAssay Description:Displacement of [3H]-CGS- 21680 from adenosine A2a receptors of rat striatal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A3(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50037435([4-(1,3-Diallyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-pu...)
Affinity DataKi:  1.73E+5nMAssay Description:Antagonist activity against rat adenosine A3 receptor using [125I]I-AB-MECA or [125 I]IABAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A3(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50037435([4-(1,3-Diallyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-pu...)
Affinity DataKi:  1.73E+5nMAssay Description:Displacement of [125I]AB-MECA from membranes of CHO cells stably transfected with the rat adenosine A3 receptor cDNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed