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BDBM50038210 5-(2-Ethyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-tetrahydro-pyridine::Alvameline::CHEMBL131428

SMILES: CCn1nnc(n1)C1=CCCN(C)C1

InChI Key: InChIKey=RNMOMKCRCIRYCZ-UHFFFAOYSA-N

Data: 1 KI  2 EC50

Find this compound or compounds like it in BindingDB or PDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50038210   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038210
PNG
(5-(2-Ethyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-tetr...)
Show SMILES CCn1nnc(n1)C1=CCCN(C)C1
Show InChI InChI=1S/C9H15N5/c1-3-14-11-9(10-12-14)8-5-4-6-13(2)7-8/h5H,3-4,6-7H2,1-2H3
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Article
PubMed
36n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50038210
PNG
(5-(2-Ethyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-tetr...)
Show SMILES CCn1nnc(n1)C1=CCCN(C)C1
Show InChI InChI=1S/C9H15N5/c1-3-14-11-9(10-12-14)8-5-4-6-13(2)7-8/h5H,3-4,6-7H2,1-2H3
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PC sid
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Article
PubMed
n/an/an/an/a 296n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay


Bioorg Med Chem Lett 25: 4158-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.011
BindingDB Entry DOI: 10.7270/Q2GM8938
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50038210
PNG
(5-(2-Ethyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-tetr...)
Show SMILES CCn1nnc(n1)C1=CCCN(C)C1
Show InChI InChI=1S/C9H15N5/c1-3-14-11-9(10-12-14)8-5-4-6-13(2)7-8/h5H,3-4,6-7H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>5.10E+4n/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
M2 agonist activity estimated by depression of isolated guinea pig left atrium


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair