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BDBM50038212 2-Ethyl-8-methyl-2,8-diaza-spiro[4.5]decane-1,3-dione::2-Ethyl-8-methyl-2,8-diaza-spiro[4.5]decane-1,3-dione (RS-86)::2-Ethyl-8-methyl-2,8-diaza-spiro[4.5]decane-1,3-dione(RS-86)::CHEMBL273308::CHEMBL542883

SMILES: CCN1C(=O)CC2(CCN(C)CC2)C1=O

InChI Key: InChIKey=UIHKDOBBVHGTAQ-UHFFFAOYSA-N

Data: 3 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50038212   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038212
PNG
(2-Ethyl-8-methyl-2,8-diaza-spiro[4.5]decane-1,3-di...)
Show SMILES CCN1C(=O)CC2(CCN(C)CC2)C1=O
Show InChI InChI=1S/C11H18N2O2/c1-3-13-9(14)8-11(10(13)15)4-6-12(2)7-5-11/h3-8H2,1-2H3
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PubMed
400n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50038212
PNG
(2-Ethyl-8-methyl-2,8-diaza-spiro[4.5]decane-1,3-di...)
Show SMILES CCN1C(=O)CC2(CCN(C)CC2)C1=O
Show InChI InChI=1S/C11H18N2O2/c1-3-13-9(14)8-11(10(13)15)4-6-12(2)7-5-11/h3-8H2,1-2H3
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460n/an/an/an/an/an/an/an/a



Institute for Drug Discovery Research

Curated by ChEMBL


Assay Description
Displacement of [3H]pirenzepine from rat cortex membrane expressing muscarinic M1 receptor


J Med Chem 36: 2292-9 (1993)


Article DOI: 10.1021/jm00068a005
BindingDB Entry DOI: 10.7270/Q2W66MDV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50038212
PNG
(2-Ethyl-8-methyl-2,8-diaza-spiro[4.5]decane-1,3-di...)
Show SMILES CCN1C(=O)CC2(CCN(C)CC2)C1=O
Show InChI InChI=1S/C11H18N2O2/c1-3-13-9(14)8-11(10(13)15)4-6-12(2)7-5-11/h3-8H2,1-2H3
PDB

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B.MOAD
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970n/an/an/an/an/an/an/an/a



Institute for Drug Discovery Research

Curated by ChEMBL


Assay Description
Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor


J Med Chem 36: 2292-9 (1993)


Article DOI: 10.1021/jm00068a005
BindingDB Entry DOI: 10.7270/Q2W66MDV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50038212
PNG
(2-Ethyl-8-methyl-2,8-diaza-spiro[4.5]decane-1,3-di...)
Show SMILES CCN1C(=O)CC2(CCN(C)CC2)C1=O
Show InChI InChI=1S/C11H18N2O2/c1-3-13-9(14)8-11(10(13)15)4-6-12(2)7-5-11/h3-8H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 400n/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
M2 agonist activity estimated by depression of isolated guinea pig left atrium


J Med Chem 37: 4085-99 (1995)


Article DOI: 10.1021/jm00050a006
BindingDB Entry DOI: 10.7270/Q21N8066
More data for this
Ligand-Target Pair