BDBM50038459 CHEMBL3353725

SMILES COc1ccc(Cc2sc(nc2O)-c2ccc(Cl)cc2)cc1

InChI Key InChIKey=WWYUTGZPTVICCK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50038459   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50038459(CHEMBL3353725)
Affinity DataIC50:  140nMAssay Description:Inhibition of 5-LO in human PMNL using arachidonic acid as substrate assessed as product formation incubated for 15 mins prior to substrate addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50038459(CHEMBL3353725)
Affinity DataIC50:  30nMAssay Description:Inhibition of 5-LO in human PMNL S100 extract using arachidonic acid as substrate incubated for 15 mins prior to substrate addition measured after 10...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50038459(CHEMBL3353725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 15-LO1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50038459(CHEMBL3353725)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 12-LO (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed