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BDBM50038865 2-Benzofuran-2-yl-1-[(R)-2-(pyrrolidine-1-carbonyl)-pyrrolidin-1-yl]-ethanone::CHEMBL304892

SMILES: O=C(Cc1cc2ccccc2o1)N1CCC[C@@H]1C(=O)N1CCCC1

InChI Key: InChIKey=SUCCKSYEEMWBIE-MRXNPFEDSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50038865   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50038865
PNG
(2-Benzofuran-2-yl-1-[(R)-2-(pyrrolidine-1-carbonyl...)
Show SMILES O=C(Cc1cc2ccccc2o1)N1CCC[C@@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C19H22N2O3/c22-18(13-15-12-14-6-1-2-8-17(14)24-15)21-11-5-7-16(21)19(23)20-9-3-4-10-20/h1-2,6,8,12,16H,3-5,7,9-11,13H2/t16-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 510n/an/an/an/an/an/a



Zeria Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against purified prolyl endopeptidase (PEP) from canine brain.


J Med Chem 37: 2071-8 (1994)


Article DOI: 10.1021/jm00039a019
BindingDB Entry DOI: 10.7270/Q270822J
More data for this
Ligand-Target Pair