BDBM50038978 Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quinazolin-4-yl)-amine::CHEMBL302299

SMILES COc1cc2c(NCc3ccc4OCOc4c3)ncnc2c(OC)c1OC

InChI Key InChIKey=OTQULNJSJQEICR-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50038978   

TargetPhosphodiesterase(Sus scrofa)
Eisai

Curated by ChEMBL
LigandPNGBDBM50038978(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Affinity DataIC50:  360nMAssay Description:Inhibition of cGMP-inhibited PDE 3 from porcine aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50038978(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of cGMP stimulated-PDE 2 from porcine aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
Eisai

Curated by ChEMBL
LigandPNGBDBM50038978(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of cAMP specific-PDE 4 from porcine aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Sus scrofa)
Eisai

Curated by ChEMBL
LigandPNGBDBM50038978(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of cGMP-inhibited PDE 3 from porcine aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
Eisai

Curated by ChEMBL
LigandPNGBDBM50038978(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of cAMP specific phosphodiesterase from porcine coronary arteriesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50038978(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Affinity DataIC50:  360nMAssay Description:Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Sus scrofa)
Eisai

Curated by ChEMBL
LigandPNGBDBM50038978(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of cGMP-inhibited phosphodiesterase from porcine coronary arteriesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50038978(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of cGMP-stimulated phosphodiesterase 2 of porcine coronary arteriesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50038978(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of [Ca(2+)]-calmodulin-dependent cGMP-phosphodiesterase 1 from porcine coronary arteriesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed