BDBM50039234 1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid::CHEMBL432737

SMILES COc1ccc(cc1)C(OCCN1CCCC(C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1

InChI Key InChIKey=VDLDUZLDZBVOAS-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50039234   

TargetSodium- and chloride-dependent GABA transporter 1(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039234(1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-pipe...)
Affinity DataIC50:  2.33E+5nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rattus norvegicus)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039234(1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-pipe...)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039234(1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-pipe...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory activity against human sodium and chloride dependent GABA transporter 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent betaine transporter(Homo sapiens (Human))
Isf College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50039234(1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-pipe...)
Affinity DataIC50:  1.40E+5nMAssay Description:Inhibition of human BGT-1 expressed in mouse L-M(TK-) cells assessed as inhibition of [3H]GABA uptakeMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium- and chloride-dependent GABA transporter 3(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039234(1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-pipe...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human GAT-3 expressed in mouse L-M(TK-) cells assessed as inhibition of [3H]GABA uptakeMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rattus norvegicus)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039234(1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-pipe...)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibition of rat GAT-2 expressed in mouse L-M(TK-) cells assessed as inhibition of [3H]GABA uptakeMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039234(1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-pipe...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human GAT-1 expressed in mouse L-M(TK-) cells assessed as inhibition of [3H]GABA uptakeMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium- and chloride-dependent betaine transporter(Homo sapiens (Human))
Isf College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50039234(1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-pipe...)
Affinity DataIC50:  2.08E+5nMAssay Description:Inhibition of human GABA transporter (hBGT-1) activity.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed