BDBM50040727 CHEMBL3353220::US9255110, 7

SMILES COc1cc2ncccc2cc1NC(=O)c1csc2cnc(nc12)N(C)CCN

InChI Key InChIKey=BUJSZRICYLPWCM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50040727   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM50040727(CHEMBL3353220 | US9255110, 7)
Affinity DataIC50:  8nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 1(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM50040727(CHEMBL3353220 | US9255110, 7)
Affinity DataIC50:  983nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM50040727(CHEMBL3353220 | US9255110, 7)
Affinity DataIC50:  8nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040727(CHEMBL3353220 | US9255110, 7)
Affinity DataIC50:  410nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 1(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM50040727(CHEMBL3353220 | US9255110, 7)
Affinity DataIC50:  983nMAssay Description:Inhibition of IRAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040727(CHEMBL3353220 | US9255110, 7)
Affinity DataIC50:  410nMpH: 7.2 T: 2°CAssay Description:SYK activity is measured by phosphorylation of a peptide substrate (Biotin-EPEGDYEEVLE) with [gamma-33P] ATP. The enzyme reaction was conducted at 20...More data for this Ligand-Target Pair
In DepthDetails US Patent