BDBM50040807 CHEMBL3361252

SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2sc3CCCc3c12

InChI Key InChIKey=URDBLCLSFRUNRD-HAQNSBGRSA-N

Data  1 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50040807   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040807(CHEMBL3361252)
Affinity DataKi:  50nMAssay Description:Inhibition of N-terminal GST-fused full-length human IRAK4 (1 to 460 amino acids) assessed as reduction in phosphorylated substrates by Caliper assayMore data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040807(CHEMBL3361252)
Affinity DataIC50:  140nMAssay Description:Inhibition of recombinant full length His-tagged human IRAK4 expressed in baculovirus expression system using 5-FAM-IPTSPITTTYFFFKKK-COOH as substrat...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040807(CHEMBL3361252)
Affinity DataIC50:  490nMAssay Description:Inhibition of IRAK4 in human KARPAS299 cells assessed as reduction in IL-1 stimulated IRAK4 phosphorylation at Thr345/Ser346 residues preincubated fo...More data for this Ligand-Target Pair