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BDBM50040823 11-(2,6-Diisopropyl-phenylcarbamoyl)-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid methyl ester::CHEMBL167198

SMILES: COC(=O)c1ccc2OCc3ccccc3C(C(=O)Nc3c(cccc3C(C)C)C(C)C)c2c1

InChI Key: InChIKey=CCKPSQMDQXIBOG-UHFFFAOYNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50040823   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50040823
PNG
(11-(2,6-Diisopropyl-phenylcarbamoyl)-6,11-dihydro-...)
Show SMILES COC(=O)c1ccc2OCc3ccccc3C(C(=O)Nc3c(cccc3C(C)C)C(C)C)c2c1
Show InChI InChI=1/C29H31NO4/c1-17(2)21-11-8-12-22(18(3)4)27(21)30-28(31)26-23-10-7-6-9-20(23)16-34-25-14-13-19(15-24(25)26)29(32)33-5/h6-15,17-18,26H,16H2,1-5H3,(H,30,31)
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Article
PubMed
n/an/a 180n/an/an/an/an/an/a



Kyowa Hakko Kogyo Company

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in liver microsomes isolated from cholesterol-fed rabbits


J Med Chem 37: 804-10 (1994)


Article DOI: 10.1021/jm00032a014
BindingDB Entry DOI: 10.7270/Q20C4TTM
More data for this
Ligand-Target Pair