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BDBM50040917 5-(Methyl-phenyl-amino)-6-phenylamino-isoindole-1,3-dione::CHEMBL7775

SMILES: CN(c1ccccc1)c1cc2C(=O)NC(=O)c2cc1Nc1ccccc1

InChI Key: InChIKey=FWGDADVNSIYRAD-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50040917   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50040917
PNG
(5-(Methyl-phenyl-amino)-6-phenylamino-isoindole-1,...)
Show SMILES CN(c1ccccc1)c1cc2C(=O)NC(=O)c2cc1Nc1ccccc1
Show InChI InChI=1S/C21H17N3O2/c1-24(15-10-6-3-7-11-15)19-13-17-16(20(25)23-21(17)26)12-18(19)22-14-8-4-2-5-9-14/h2-13,22H,1H3,(H,23,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Ciba-Geigy Limited

Curated by ChEMBL


Assay Description
Inhibition of EGF-dependent autophosphorylation of EGF-R in human A431 cells


J Med Chem 37: 1015-27 (1994)


Article DOI: 10.1021/jm00033a019
BindingDB Entry DOI: 10.7270/Q2M32TTP
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL


(Homo sapiens (Human))
BDBM50040917
PNG
(5-(Methyl-phenyl-amino)-6-phenylamino-isoindole-1,...)
Show SMILES CN(c1ccccc1)c1cc2C(=O)NC(=O)c2cc1Nc1ccccc1
Show InChI InChI=1S/C21H17N3O2/c1-24(15-10-6-3-7-11-15)19-13-17-16(20(25)23-21(17)26)12-18(19)22-14-8-4-2-5-9-14/h2-13,22H,1H3,(H,23,25,26)
PDB

KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Ciba-Geigy Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against v-abl tyrosine kinase


J Med Chem 37: 1015-27 (1994)


Article DOI: 10.1021/jm00033a019
BindingDB Entry DOI: 10.7270/Q2M32TTP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50040917
PNG
(5-(Methyl-phenyl-amino)-6-phenylamino-isoindole-1,...)
Show SMILES CN(c1ccccc1)c1cc2C(=O)NC(=O)c2cc1Nc1ccccc1
Show InChI InChI=1S/C21H17N3O2/c1-24(15-10-6-3-7-11-15)19-13-17-16(20(25)23-21(17)26)12-18(19)22-14-8-4-2-5-9-14/h2-13,22H,1H3,(H,23,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Ciba-Geigy Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against c-src tyrosine kinase


J Med Chem 37: 1015-27 (1994)


Article DOI: 10.1021/jm00033a019
BindingDB Entry DOI: 10.7270/Q2M32TTP
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50040917
PNG
(5-(Methyl-phenyl-amino)-6-phenylamino-isoindole-1,...)
Show SMILES CN(c1ccccc1)c1cc2C(=O)NC(=O)c2cc1Nc1ccccc1
Show InChI InChI=1S/C21H17N3O2/c1-24(15-10-6-3-7-11-15)19-13-17-16(20(25)23-21(17)26)12-18(19)22-14-8-4-2-5-9-14/h2-13,22H,1H3,(H,23,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 8.70E+3n/an/an/an/an/an/a



Ciba-Geigy Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant tyrosine kinase EGF-R (EGF-R ICD)


J Med Chem 37: 1015-27 (1994)


Article DOI: 10.1021/jm00033a019
BindingDB Entry DOI: 10.7270/Q2M32TTP
More data for this
Ligand-Target Pair
Cyclic AMP-dependent protein kinase (PKA)


(Oryctolagus cuniculus (Rabbit))
BDBM50040917
PNG
(5-(Methyl-phenyl-amino)-6-phenylamino-isoindole-1,...)
Show SMILES CN(c1ccccc1)c1cc2C(=O)NC(=O)c2cc1Nc1ccccc1
Show InChI InChI=1S/C21H17N3O2/c1-24(15-10-6-3-7-11-15)19-13-17-16(20(25)23-21(17)26)12-18(19)22-14-8-4-2-5-9-14/h2-13,22H,1H3,(H,23,25,26)
PDB
MMDB

KEGG

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Ciba-Geigy Limited

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against protein kinase A (PKA) of rabbit


J Med Chem 37: 1015-27 (1994)


Article DOI: 10.1021/jm00033a019
BindingDB Entry DOI: 10.7270/Q2M32TTP
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM50040917
PNG
(5-(Methyl-phenyl-amino)-6-phenylamino-isoindole-1,...)
Show SMILES CN(c1ccccc1)c1cc2C(=O)NC(=O)c2cc1Nc1ccccc1
Show InChI InChI=1S/C21H17N3O2/c1-24(15-10-6-3-7-11-15)19-13-17-16(20(25)23-21(17)26)12-18(19)22-14-8-4-2-5-9-14/h2-13,22H,1H3,(H,23,25,26)
MMDB

KEGG

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.20E+4n/an/an/an/an/an/a



Ciba-Geigy Limited

Curated by ChEMBL


Assay Description
Inhibition of PDGF-dependent autophosphorylation of PDGF-R in mouse BALB/c3T3 cells


J Med Chem 37: 1015-27 (1994)


Article DOI: 10.1021/jm00033a019
BindingDB Entry DOI: 10.7270/Q2M32TTP
More data for this
Ligand-Target Pair