BDBM50041010 BAY-736691::CHEMBL1513993

SMILES C[C@H](Cc1nc2n(ncc2c(=O)[nH]1)-c1ccccc1Cl)C(F)(F)F

InChI Key InChIKey=FFPXPXOAFQCNBS-MRVPVSSYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50041010   

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50041010(BAY-736691 | CHEMBL1513993)
Affinity DataIC50:  55nMAssay Description:Inhibition of human PDE9A2 using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50041010(BAY-736691 | CHEMBL1513993)
Affinity DataIC50:  50nMAssay Description:Inhibition of recombinant PDE9A2 catalytic domain (unknown origin) expressed in Escherichia coli BL21 using [3H]cGMP as substrate after 15 mins by li...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50041010(BAY-736691 | CHEMBL1513993)
Affinity DataIC50:  22nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21-CodonPlus cells using [3H]cGMP or [3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50041010(BAY-736691 | CHEMBL1513993)
Affinity DataIC50:  22nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21-CodonPlus cells using [3H]cGMP or [3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50041010(BAY-736691 | CHEMBL1513993)
Affinity DataIC50:  50nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed