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BDBM50041131 6-(4-Dimethylamino-phenyl)-5H-[1,3]dioxolo[4,5-g]quinolin-8-one::CHEMBL279811

SMILES: CN(C)c1ccc(cc1)-c1cc(O)c2cc3OCOc3cc2n1

InChI Key: InChIKey=GUYRKUKTQPPPFK-UHFFFAOYSA-N

Data: 1 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50041131   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tubulin


(Bos taurus)
BDBM50041131
PNG
(6-(4-Dimethylamino-phenyl)-5H-[1,3]dioxolo[4,5-g]q...)
Show SMILES CN(C)c1ccc(cc1)-c1cc(O)c2cc3OCOc3cc2n1
Show InChI InChI=1S/C18H16N2O3/c1-20(2)12-5-3-11(4-6-12)14-8-16(21)13-7-17-18(23-10-22-17)9-15(13)19-14/h3-9H,10H2,1-2H3,(H,19,21)
PDB
MMDB

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Similars

Article
PubMed
n/an/a>4.00E+4n/an/an/an/an/an/a



School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization


J Med Chem 37: 1126-35 (1994)


Article DOI: 10.1021/jm00034a010
BindingDB Entry DOI: 10.7270/Q2ZC81XN
More data for this
Ligand-Target Pair