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BDBM50041921 5-{4-[2-(3,4,5-Trimethoxy-phenyl)-ethyl]-phenyl}-2,3-dihydro-imidazo[2,1-a]isoquinoline::CHEMBL449395::SDZ-64-412

SMILES: COc1cc(CCc2ccc(cc2)C2=Cc3ccccc3C3=NCCN23)cc(OC)c1OC

InChI Key: InChIKey=FKRBSORUVOGNEK-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50041921   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50041921
PNG
(5-{4-[2-(3,4,5-Trimethoxy-phenyl)-ethyl]-phenyl}-2...)
Show SMILES COc1cc(CCc2ccc(cc2)C2=Cc3ccccc3C3=NCCN23)cc(OC)c1OC
Show InChI InChI=1S/C28H28N2O3/c1-31-25-16-20(17-26(32-2)27(25)33-3)9-8-19-10-12-21(13-11-19)24-18-22-6-4-5-7-23(22)28-29-14-15-30(24)28/h4-7,10-13,16-18H,8-9,14-15H2,1-3H3
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PC cid
PC sid
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Similars

Article
n/an/a 40n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes


Bioorg Med Chem Lett 3: 1493-1498 (1993)


Article DOI: 10.1016/S0960-894X(00)80005-0
BindingDB Entry DOI: 10.7270/Q2H132H9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50041921
PNG
(5-{4-[2-(3,4,5-Trimethoxy-phenyl)-ethyl]-phenyl}-2...)
Show SMILES COc1cc(CCc2ccc(cc2)C2=Cc3ccccc3C3=NCCN23)cc(OC)c1OC
Show InChI InChI=1S/C28H28N2O3/c1-31-25-16-20(17-26(32-2)27(25)33-3)9-8-19-10-12-21(13-11-19)24-18-22-6-4-5-7-23(22)28-29-14-15-30(24)28/h4-7,10-13,16-18H,8-9,14-15H2,1-3H3
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CHEMBL
PC cid
PC sid
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Article
PubMed
n/an/a 60n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
In vitro PAF antagonistic activity by determining [3H]-PAF binding to the PAF-receptor of human platelets


J Med Chem 36: 3098-102 (1993)


Article DOI: 10.1021/jm00073a008
BindingDB Entry DOI: 10.7270/Q27P8XFQ
More data for this
Ligand-Target Pair