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BDBM50042230 2-Butyl-3-[2'-(1-methyl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1,3-diaza-spiro[4.4]non-1-en-4-one::CHEMBL115193

SMILES: CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(cc1)-c1ccccc1-c1nnnn1C

InChI Key: InChIKey=YDXKLVLFROFBFN-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50042230   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II AT1B


(RAT)
BDBM50042230
PNG
(2-Butyl-3-[2'-(1-methyl-1H-tetrazol-5-yl)-biphenyl...)
Show SMILES CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(cc1)-c1ccccc1-c1nnnn1C
Show InChI InChI=1S/C26H30N6O/c1-3-4-11-23-27-26(16-7-8-17-26)25(33)32(23)18-19-12-14-20(15-13-19)21-9-5-6-10-22(21)24-28-29-30-31(24)2/h5-6,9-10,12-15H,3-4,7-8,11,16-18H2,1-2H3
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Article
PubMed
n/an/a 150n/an/an/an/an/an/a



Sanofi Recherche

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membran...


J Med Chem 36: 3371-80 (1993)


Article DOI: 10.1021/jm00074a018
BindingDB Entry DOI: 10.7270/Q22Z14M0
More data for this
Ligand-Target Pair