BDBM50042523 CHEMBL333100::N-[6-(4-Trifluoromethyl-benzyloxy)-2H-chromen-3-ylmethyl]-hydroxylurea

SMILES NC(=O)N(O)CC1=Cc2cc(OCc3ccc(cc3)C(F)(F)F)ccc2OC1

InChI Key InChIKey=IGMADJRUJCQGKS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50042523   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042523(N-[6-(4-Trifluoromethyl-benzyloxy)-2H-chromen-3-yl...)
Affinity DataIC50: 430nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase by reduction of 5-hydroxyeicosatetraenoic acid (5-HETE) formed in guinea pig polymorphonuclear le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042523(N-[6-(4-Trifluoromethyl-benzyloxy)-2H-chromen-3-yl...)
Affinity DataIC50: 490nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase by reduction of LTB4 formed in guinea pig polymorphonuclear leukocytes (PMNs).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed