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BDBM50042538 5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2-(2,2,2-trifluoro-ethyl)-2H-pyrazole-3-carboxylic acid::CHEMBL281386

SMILES: CCCCc1nn(CC(F)(F)F)c(C(O)=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1

InChI Key: InChIKey=HNVFKNSAAWSQJP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50042538   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50042538
PNG
(5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Show SMILES CCCCc1nn(CC(F)(F)F)c(C(O)=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C24H23F3N6O2/c1-2-3-8-20-19(21(23(34)35)33(30-20)14-24(25,26)27)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-28-31-32-29-22/h4-7,9-12H,2-3,8,13-14H2,1H3,(H,34,35)(H,28,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 0.520n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1


J Med Chem 36: 3595-605 (1994)


Article DOI: 10.1021/jm00075a014
BindingDB Entry DOI: 10.7270/Q25Q4V5H
More data for this
Ligand-Target Pair