BindingDB logo
myBDB logout

BDBM50042627 CHEMBL123417::Sodium; 7-[4-(4-fluoro-phenyl)-5-pyridin-3-yl-2-trifluoromethyl-imidazol-1-yl]-3,5-dihydroxy-heptanoate

SMILES: O[C@H](CCn1c(nc(c1-c1cccnc1)-c1ccc(F)cc1)C(F)(F)F)C[C@@H](O)CC([O-])=O

InChI Key: InChIKey=YLIOTEUATHEBPA-IAGOWNOFSA-M

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50042627   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50042627
PNG
(CHEMBL123417 | Sodium; 7-[4-(4-fluoro-phenyl)-5-py...)
Show SMILES O[C@H](CCn1c(nc(c1-c1cccnc1)-c1ccc(F)cc1)C(F)(F)F)C[C@@H](O)CC([O-])=O
Show InChI InChI=1S/C22H21F4N3O4/c23-15-5-3-13(4-6-15)19-20(14-2-1-8-27-12-14)29(21(28-19)22(24,25)26)9-7-16(30)10-17(31)11-18(32)33/h1-6,8,12,16-17,30-31H,7,9-11H2,(H,32,33)/p-1/t16-,17-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Glaxo Group Research Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)


J Med Chem 36: 3646-57 (1994)


Article DOI: 10.1021/jm00075a020
BindingDB Entry DOI: 10.7270/Q2X929CH
More data for this
Ligand-Target Pair