BDBM50042949 (E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one (21)::(E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one::(E)-3-(3,4-Dihydroxy-phenyl)-1-(2,4-dihydroxy-phenyl)-propenone::3,4,2',4'-tetrahydroxychalone::3-(3,4-Dihydroxy-phenyl)-1-(2,4-dihydroxy-phenyl)-propenone::Butein::CHEMBL128000
SMILES Oc1ccc(C(=O)\C=C\c2ccc(O)c(O)c2)c(O)c1
InChI Key InChIKey=AYMYWHCQALZEGT-ORCRQEGFSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 23 hits for monomerid = 50042949
TargetEnoyl-acyl-carrier protein reductase(Plasmodium falciparum)
National Institute Of Immunology
Curated by ChEMBL
National Institute Of Immunology
Curated by ChEMBL
Affinity DataKi: 14nMAssay Description:Inhibition of Plasmodium falciparum ENR in presence of triclosanMore data for this Ligand-Target Pair
TargetEnoyl-acyl-carrier protein reductase(Plasmodium falciparum)
National Institute Of Immunology
Curated by ChEMBL
National Institute Of Immunology
Curated by ChEMBL
Affinity DataKi: 2.97E+3nMAssay Description:Inhibition of Plasmodium falciparum ENR using crotonyl-CoA substrateMore data for this Ligand-Target Pair
TargetEnoyl-acyl-carrier protein reductase(Plasmodium falciparum)
National Institute Of Immunology
Curated by ChEMBL
National Institute Of Immunology
Curated by ChEMBL
Affinity DataKi: 5.50E+3nMAssay Description:Inhibition of Plasmodium falciparum ENR using NADH substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Griffith University
Curated by ChEMBL
Griffith University
Curated by ChEMBL
Affinity DataIC50: 6.50E+4nMAssay Description:Inhibition of c-SrcMore data for this Ligand-Target Pair
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Northern Kentucky University
Curated by ChEMBL
Northern Kentucky University
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of bovine xanthine oxidase assessed as conversion of xanthine to uric acid by spectroscopic analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 730nMAssay Description:Inhibition of ACE in rabbit lung assessed as decrease in dansylglycine concentration after 5 mins by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 7.30E+5nMAssay Description:Inhibition of rabbit lung ACE assessed as reduction in hippuryl-histidyl-leucine substrate by colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Compound concentration required to reduce HIV-1 Integrase 3'-processing activity by 50%More data for this Ligand-Target Pair
TargetEnoyl-acyl-carrier protein reductase(Plasmodium falciparum)
National Institute Of Immunology
Curated by ChEMBL
National Institute Of Immunology
Curated by ChEMBL
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of Plasmodium falciparum ENRMore data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Escherichia coli)
National Institute Of Immunology
Curated by ChEMBL
National Institute Of Immunology
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Escherichia coli ENRMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of 5-lipoxygenase in rat RBL1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against HIV-1 Integrase (HIV-1-IN)More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Griffith University
Curated by ChEMBL
Griffith University
Curated by ChEMBL
Affinity DataIC50: 6.50E+4nMAssay Description:Inhibition of p60 c-SrcMore data for this Ligand-Target Pair
Affinity DataKd: 1.00E+5nMAssay Description:Binding affinity to CDK2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1/2(Homo sapiens (Human))
Tokushima Bunri University
Curated by ChEMBL
Tokushima Bunri University
Curated by ChEMBL
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of Prostaglandin G/H synthase activity in sheep seminal vesicle was determined 100 uMMore data for this Ligand-Target Pair
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
University Of Basel
Curated by ChEMBL
University Of Basel
Curated by ChEMBL
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation countin...More data for this Ligand-Target Pair
Affinity DataIC50: 450nMAssay Description:Inhibition of Rattus norvegicus (rat) lens aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 7.30E+8nMAssay Description:Inhibition of rabbit lung ACE assessed as inhibition of hippuryl-histidyl-leucine substrate hydrolysis pretreated for 10 mins followed by addition of...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
National Cheng Kung University
Curated by ChEMBL
National Cheng Kung University
Curated by ChEMBL
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
Affinity DataIC50: 2.37E+3nMpH: 4.5 T: 2°CAssay Description:The assay based on fluorescenceresonance energy transfer was carried out with BACE1 enzyme at pH 4.5 with a substrate, H-Lys(DABSYL)-SEVNLDAEFR-Gin-(...More data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair