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BDBM50044438 8-[4-(4-Fluoro-phenyl)-butyl]-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL84542

SMILES: Fc1ccc(CCCCN2CCC3(CC2)N(CNC3=O)c2ccccc2)cc1

InChI Key: InChIKey=NNXYSTMMMHUVPK-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50044438   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50044438
PNG
(8-[4-(4-Fluoro-phenyl)-butyl]-1-phenyl-1,3,8-triaz...)
Show SMILES Fc1ccc(CCCCN2CCC3(CC2)N(CNC3=O)c2ccccc2)cc1
Show InChI InChI=1S/C23H28FN3O/c24-20-11-9-19(10-12-20)6-4-5-15-26-16-13-23(14-17-26)22(28)25-18-27(23)21-7-2-1-3-8-21/h1-3,7-12H,4-6,13-18H2,(H,25,28)
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
5n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Tested for binding affinity against 5-hydroxytryptamine 2 receptor from rat frontal cortical regions using [3H]ketanserin as radioligand


J Med Chem 36: 2519-25 (1993)


Article DOI: 10.1021/jm00069a010
BindingDB Entry DOI: 10.7270/Q2QF8RZ9
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50044438
PNG
(8-[4-(4-Fluoro-phenyl)-butyl]-1-phenyl-1,3,8-triaz...)
Show SMILES Fc1ccc(CCCCN2CCC3(CC2)N(CNC3=O)c2ccccc2)cc1
Show InChI InChI=1S/C23H28FN3O/c24-20-11-9-19(10-12-20)6-4-5-15-26-16-13-23(14-17-26)22(28)25-18-27(23)21-7-2-1-3-8-21/h1-3,7-12H,4-6,13-18H2,(H,25,28)
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
110n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Tested for binding affinity against 5-hydroxytryptamine 1A receptor from rat frontal cortical regions using [3H]-8-OH-DPAT as radioligand


J Med Chem 36: 2519-25 (1993)


Article DOI: 10.1021/jm00069a010
BindingDB Entry DOI: 10.7270/Q2QF8RZ9
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2c (5HT2A and 5HT2C)


(Rattus norvegicus (Rat))
BDBM50044438
PNG
(8-[4-(4-Fluoro-phenyl)-butyl]-1-phenyl-1,3,8-triaz...)
Show SMILES Fc1ccc(CCCCN2CCC3(CC2)N(CNC3=O)c2ccccc2)cc1
Show InChI InChI=1S/C23H28FN3O/c24-20-11-9-19(10-12-20)6-4-5-15-26-16-13-23(14-17-26)22(28)25-18-27(23)21-7-2-1-3-8-21/h1-3,7-12H,4-6,13-18H2,(H,25,28)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
3.20E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Tested for binding affinity against 5-hydroxytryptamine 1C receptor from rat frontal cortical regions using [3H]-mesulergine as radioligand


J Med Chem 36: 2519-25 (1993)


Article DOI: 10.1021/jm00069a010
BindingDB Entry DOI: 10.7270/Q2QF8RZ9
More data for this
Ligand-Target Pair