BDBM50044452 8-Phenethyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL84079

SMILES O=C1NCN(c2ccccc2)C11CCN(CCc2ccccc2)CC1

InChI Key InChIKey=VBFCKBBGHPJVIS-UHFFFAOYSA-N

Data  3 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50044452   

TargetSerotonin 2 (5-HT2) receptor(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50044452(8-Phenethyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-...)
Affinity DataKi:  570nMAssay Description:Tested for binding affinity against 5-hydroxytryptamine 2 receptor from rat frontal cortical regions using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50044452(8-Phenethyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-...)
Affinity DataKi:  1.03E+3nMAssay Description:Tested for binding affinity against 5-hydroxytryptamine 1A receptor from rat frontal cortical regions using [3H]8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50044452(8-Phenethyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-...)
Affinity DataKi:  6.00E+3nMAssay Description:Tested for binding affinity against 5-hydroxytryptamine 1C receptor from rat frontal cortical regions using [3H]mesulergine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50044452(8-Phenethyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of [3H]glycine uptake in cells transfected with human GlyT1 cDNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed