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BDBM50044513 2-{3-Butyl-5-oxo-4-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,5-dihydro-[1,2,4]triazol-1-yl}-3-methyl-butyric acid::CHEMBL446152

SMILES: CCCCc1nn(C(C(C)C)C(O)=O)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1

InChI Key: InChIKey=XSILPQTUKBRCSE-UHFFFAOYNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50044513   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50044513
PNG
(2-{3-Butyl-5-oxo-4-[2'-(2H-tetrazol-5-yl)-biphenyl...)
Show SMILES CCCCc1nn(C(C(C)C)C(O)=O)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1/C25H29N7O3/c1-4-5-10-21-28-32(22(16(2)3)24(33)34)25(35)31(21)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-26-29-30-27-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,33,34)(H,26,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without usi...


J Med Chem 36: 2558-68 (1993)


Article DOI: 10.1021/jm00069a015
BindingDB Entry DOI: 10.7270/Q2KP817C
More data for this
Ligand-Target Pair