BDBM50045683 4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-4-oxo-butyramide::CHEMBL94762

SMILES NC1CCN(CC1)C(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)[C@@H](O)CCc1ccccn1

InChI Key InChIKey=LGVOTNOMAMGKRU-XHRNTERESA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50045683   

TargetPepsin A-5(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045683(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50: >1.00E+5nMAssay Description:Selectivity against human pepsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045683(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50:  0.390nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastricsin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045683(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50: >1.00E+5nMAssay Description:Selectivity against human gastricsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Rattus norvegicus)
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045683(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50:  2.55E+3nMAssay Description:Selectivity against rat plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045683(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50: >1.00E+5nMAssay Description:Selectivity against human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045683(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of human plasma renin assessed as reduction in endogenous angiotensin 1 production in plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045683(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50:  15nMAssay Description:Selectivity against dog plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045683(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045683(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50:  0.380nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045683(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50:  0.240nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045683(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50:  5.5nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045683(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50: >1.00E+5nMAssay Description:Selectivity against human cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed