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BDBM50045972 (2-Methyl-pyridin-3-yl)-[4-(4,4,4-trifluoro-3-hydroxy-3-phenyl-butyryl)-piperazin-1-yl]-acetonitrile::CHEMBL100894

SMILES: Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(O)(c1ccccc1)C(F)(F)F

InChI Key: InChIKey=RBBXNISSVQRRRT-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50045972   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045972
PNG
((2-Methyl-pyridin-3-yl)-[4-(4,4,4-trifluoro-3-hydr...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(O)(c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C22H23F3N4O2/c1-16-18(8-5-9-27-16)19(15-26)28-10-12-29(13-11-28)20(30)14-21(31,22(23,24)25)17-6-3-2-4-7-17/h2-9,19,31H,10-14H2,1H3
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Similars

Article
PubMed
n/an/a 14n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced platelet aggregation in male rabbits


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair