BDBM50048291 6-(3-Adamantan-1-yl-4-hydroxy-phenyl)-naphthalene-2-carboxylic acid::6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid::6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthoic acid::CHEMBL1180::O-Demethylated Adapalene

SMILES O=C(O)c1ccc2cc(-c3ccc(O)c(C45CC6CC(CC(C6)C4)C5)c3)ccc2c1

InChI Key InChIKey=LDGIHZJOIQSHPB-UHFFFAOYSA-N

Data  3 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50048291   

TargetRetinoic acid receptor gamma(Human)
Nestle Skin Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50048291BDBM50048291(6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalen...)
Affinity DataEC50:  49nMAssay Description:Agonist activity at GAL4 DNA-binding domain-tagged RARgamma (unknown origin) ligand-binding domain expressed in human HG5LN cells incubated for 18 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetRetinoic acid receptor gamma(Human)
Nestle Skin Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50048291BDBM50048291(6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalen...)
Affinity DataKi:  77nMAssay Description:Binding affinity to retinoic acid receptor (RAR) gamma using [3H]CD 367 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRetinoic acid receptor beta(Human)
Nestle Skin Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50048291BDBM50048291(6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalen...)
Affinity DataEC50:  226nMAssay Description:Agonist activity at GAL4 DNA-binding domain-tagged RARbeta (unknown origin) ligand-binding domain expressed in human HG5LN cells incubated for 18 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetRetinoic acid receptor beta(Human)
Nestle Skin Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50048291BDBM50048291(6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalen...)
Affinity DataKi:  2.48E+3nMAssay Description:Binding affinity to retinoic acid receptor beta using [3H]CD 367 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRetinoic acid receptor alpha(Human)
Cird Galderma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50048291BDBM50048291(6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalen...)
Affinity DataKi:  6.50E+3nMAssay Description:Binding affinity to retinoic acid receptor alpha using [3H]CD 367 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRetinoic acid receptor alpha(Human)
Cird Galderma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50048291BDBM50048291(6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalen...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at GAL4 DNA-binding domain-tagged RARalpha (unknown origin) ligand-binding domain expressed in human HG5LN cells incubated for 18 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed